【摘要】

目的 探讨家庭干预模式联合注射丙戊酸钠对脑胶质瘤患者围术期应激指标及术后焦虑抑郁情绪的影响。
方法 收集因脑胶质瘤在我院住院行手术治疗的93例患者，根据干预方式不同分为观察组与对照组，其中对照组有患者46例在围术期行家庭干预模式，观察组47例在对照组基础上注射丙戊酸钠治疗。比较两组围术期应激指标及术后情绪状态改善情况。
结果 干预后观察组的焦虑评分（SAS）、抑郁评分（SDS）、舒张压（DBP）、收缩压（SBP）及心率（HR）水平均低于对照组（P<0.05）；观察组总有效率高于对照组（P<0.05）；两组不良反应对比无意义（P>0.05）。
结论 注射丙戊酸钠联合家庭干预可有效改善脑胶质瘤患者术后焦虑抑郁情绪，减轻围术期应激反应，具有较高的安全性。

【Abstract】

Objective To investigate the effect of combined intervention with sodium valproate on perioperative stress index and postoperative anxiety and depression in patients with glioma.
Methods 93 patients who underwent surgical treatment for glioma in our hospital were enrolled. The patients were divided into observation group and control group according to different intervention methods. Among them, 46 patients in the control group underwent home intervention mode during the perioperative period. Observation group 47 The case was treated with sodium valproate on the basis of the control group. Perioperative stress indicators and postoperative emotional status improvement were compared between the two groups.
Results After the intervention, the anxiety score (SAS), depression score (SDS), diastolic blood pressure (DBP), systolic blood pressure (SBP) and heart rate (HR) were lower in the observation group than in the control group (P<0.05). The efficiency was higher than that of the control group (P<0.05); the adverse reactions of the two groups were not meaningful (P>0.05).
Conclusion   Injection of sodium valproate combined with family intervention can effectively improve postoperative anxiety and depression in patients with glioma and reduce perioperative stress response, which has high safety.