本刊首页 > 期刊目次 > 高压氧辅助治疗在重度阻塞性睡眠呼吸暂停低通气综合征患者记忆和事件相关电位中的作用

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高压氧辅助治疗在重度阻塞性睡眠呼吸暂停低通气综合征患者记忆和事件相关电位中的作用

  • 许媛美

* 通信作者: 许媛美, 单位:广元市第四人民医院 628001

摘要


目的:探讨高压氧辅助治疗在改善重度阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者记忆和事件相关电位中的临床价值。

方法:选取2016年12月~2018年12月就诊于本院的重度OSAHS患者共110例作为研究对象,采用随机数表法将其分为实验组(55例)和对照组(55例),对照组采用常规治疗,实验组在常规治疗基础上加用高压氧治疗,治疗前后两组均进行PSG监测及韦氏记忆量表检测,治疗结束后加测事件相关电位P300。

结果:治疗前两组最低血氧饱和度、最长呼吸暂停时间及呼吸暂停低通气指数(AHI)比较无明显差异(P>0.05),治疗后各项指标均明显改善,实验组最低血氧饱和度明显高于对照组(t =6.732,P<0.05),最长呼吸暂停时间及呼吸暂停低通气指数明显低于对照组(t =9.236,P<0.05;t =14.888,P<0.05);事件相关电位P300检测

结果显示,实验组Cz、Pz点的潜伏期明显短于对照组(t =5.115,P<0.05;t =8.349,P<0.05),波幅明显高于对照组(t =3.364,P<0.05;t =2.883,P<0.05),反应时间也明显短于对照组(t =5.354,P<0.05);治疗前两组记忆商评分

结果比较无明显差异(P>0.05),治疗后均明显高于治疗前,且实验组明显高于对照组(t =5.608,P<0.05)。

结论:使用高压氧辅助治疗OSAHS效果显著,能有效改善患者记忆功能,且韦氏记忆量表与事件相关电位P300表现一致。

关键词:高压氧;阻塞性睡眠呼吸暂停综合征;记忆;事件相关电位

ABSTRACT


Objective: To explore the clinical value of hyperbaric oxygen assisted treatment in improving memory and event-related potentials in patients with senere obstructive sleep apnea syndrome hypopnea syndrome (OSAHS).

Methods: 110 OSAHS patients were selected from December 2016 to December 2018. They were divided into experimental group (55 cases) and control group (55 cases) by random number table method. The control group was treated with routine therapy. The experimental group was treated with hyperbaric oxygen on the basis of routine treatment. PSG monitoring and Webster's Memory Scale were performed in both groups before and after treatment.And after treatment, add event related potential P300.Result: There was no significant difference in the minimum oxygen saturation, the longest apnea time and the suspended hypopnea index between the two groups before treatment (P>0.05). After treatment, all indexes were significantly improved. The minimum oxygen saturation of the experimental group was significantly higher than that of the control group (t =6.732,P<0.05). The most frequent apnea time and suspended hypopnea index were significantly lower than the control group (t =9.236,P<0.05;t =14.888,P<0.05). The detection results of potential P300 showed that the incubation period of Cz and Pz points in the experimental group was significantly shorter than that of the control group (t =5.115,P<0.05;t =8.349,P<0.05), the amplitude was significantly higher than that of the control group (t =3.364,P<0.05;t =2.883,P<0.05), and the reaction time was also significantly shorter than the control group (t =5.354,P<0.05). There was no significant difference between the two groups (P>0.05). The scores of the two groups were significantly higher than those before treatment, and the experimental group was significantly higher than the control group (t =5.608,P<0.05).

Conclusion  : The use of hyperbaric oxygen for the treatment of OSAS is effective, can effectively improve the patient's memory function, and the Webster memory scale was consistent with the event related potential P300.

Key words: hyperbaric oxygen; obstructive sleep apnea hypopnea syndrome(OSAHS); memory function; event-related potential

引用本文 / How to Cite This Article

许媛美.高压氧辅助治疗在重度阻塞性睡眠呼吸暂停低通气综合征患者记忆和事件相关电位中的作用[J]. 国际精神病学杂志, , (): -

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