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焦虑情绪和妊娠高血压妇女血压变异性、内皮素-1、一氧化氮的关系研究

  • 程建荣

* 通信作者: 程建荣, 单位:河南省淮滨县妇幼保健院

摘要


目的:探究焦虑情绪对妊娠高血压妇女血压变异性(BPV)、内皮素-1(ET-1)以及一氧化氮(NO)的影响及关系。

方法:选取2018年4月至2019年8月于我院接受治疗的144例妊娠高血压妇女为研究对象,根据焦虑自评量表(SAS)评分将患者分为对照组、观察组1和观察组2。其中58例单纯妊娠高血压患者为对照组,49例妊娠高血压合并轻度焦虑患者为观察组1,37例妊娠高血压合并中重度焦虑患者为观察组2。比较三组患者24h收缩压标准差、24h舒张压标准差、昼间收缩压标准差、昼间舒张压标准差、夜间收缩压标准差以及夜间舒张压标准差等BPV指标;比较两组患者ET-1和NO水平;使用logistics多因素回归分析研究BPV各指标与ET-1、NO之间的关系。

结果:BPV指标比较发现,三组患者24h收缩压标准差、昼间收缩压标准差、夜间收缩压标准差以及夜间舒张压标准差比较差异有统计学意义,且观察组2以上指标较其他两组均处于更高水平,P<0.05。ET-1和NO比较发现,对照组ET-1水平58.34±16.78ng/L、NO水平81.22±6.84μmol/L,观察组1ET-1水平76.98±20.51ng/L、NO水平70.02±9.45μmol/L,观察组2ET-1水平95.30±18.77ng/L、NO水平64.32±5.19μmol/L,数据差异有统计学意义P<0.05。logistics多因素回归分析显示24h收缩压标准差、夜间收缩压标准差以及夜间舒张压标准差是影响ET-1和NO水平的相关因素,差异有统计学意义P<0.05。

结论:焦虑情绪能够影响妊娠高血压妇女血压变异性,从而进一步引起内皮素-1和一氧化氮含量的变化,早期识别妊娠高血压妇女焦虑情况对于降低内皮功能受损、改善高血压病情有积极意义。

关键词:焦虑;妊娠高血压;血压变异性;内皮素-1;一氧化氮

ABSTRACT


Objective: To explore the effect of anxiety on blood pressure variability (BPV), endothelin-1 (ET-1) and nitric oxide (NO) in pregnant women with hypertension.

Methods: 144 pregnant women with hypertension who were treated in our hospital from April 2018 to August 2019 were selected as the study objects. According to the SAS score, the patients were divided into control group, observation group 1 and observation group 2. 58 cases of PIH were in the control group, 49 cases of PIH with mild anxiety were in the observation group 1, 37 cases of PIH with moderate or severe anxiety were in the observation group 2. BPV indexes such as 24-hour systolic standard deviation, 24-hour diastolic standard deviation, daytime systolic standard deviation, daytime diastolic standard deviation, nighttime systolic standard deviation and nighttime diastolic standard deviation were compared among the three groups; ET-1 and NO levels were compared between the two groups; the relationship between BPV indexes and ET-1 and NO was studied by logistic multi factor regression analysis.

Results: A comparison of BPV indicators found that the difference smaller than the standard difference of 24h systolic pressure, the standard difference of systolic pressure between the three groups, the standard difference of night systolic pressure and the standard difference of night systolic pressure was statistically significant, and the index above 2 of the observation group was at a higher level, P<0.05. Compared with NO and ET-1, ET-1 level in control group was 58.34 ± 16.78ng/l, NO level was 81.22 ± 6.84 μ mol / L, ET-1 level in observation group was 76.98 ± 20.51ng/l, NO level was 70.02 ± 9.45 μ mol / L, ET-1 level in observation group was 95.30 ± 18.77ng/l, NO level was 64.32 ± 5.19 μ mol / L, with statistical significance P < 0.05. Logistic regression analysis showed that 24-hour systolic blood pressure standard deviation, night systolic blood pressure standard deviation and night diastolic blood pressure standard deviation were the related factors affecting the level of ET-1 and no, the difference was statistically significant (P < 0.05).

Conclusion  : anxiety can affect the blood pressure variability of pregnant women with hypertension, and further cause the changes of endothelin-1 and nitric oxide content. Early recognition of anxiety in pregnant women with hypertension is of positive significance to reduce the impairment of endothelial function and improve the condition of hypertension.

Key words: anxiety; pregnancy hypertension; blood pressure variability; endothelin-1; nitric oxide

引用本文 / How to Cite This Article

程建荣.焦虑情绪和妊娠高血压妇女血压变异性、内皮素-1、一氧化氮的关系研究[J]. 国际精神病学杂志, 2021, 48(5): 858-861

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