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小剂量奥氮平联合阿立哌唑对精神分裂症认知功能及催乳素的影响

  • 张航雷

* 通信作者: 张航雷, 单位:商丘市第二人民医院

摘要


目的 探讨小剂量奥氮平联合阿立哌唑治疗精神分裂症的临床疗效、认知功能及催乳素水平的影响。

方法 收集90例精神分裂症患者,随机分为两组,研究组45例,对照组 45 例。对照组给予阿立哌唑治疗,研究组在对照组的基础上加用小剂量奥氮平,对比两组疗效、对患者认知功能以及催乳素水平的影响。

结果 治疗后研究组 PANSS 评分明显低于对照组(P<0.05),且患者认知功能改善情况优于对照组(P<0.05),研究组与对照组相比治疗后催乳素水平无明显差异(P>0.05)。

结论 小剂量奥氮平联合阿立哌唑治疗精神分裂症,可显著改善患者阴性和阳性症状和认知功能,同时对催乳素水平影响较小。

关键词:奥氮平;阿立哌唑;精神分裂症;认知功能;催乳素

ABSTRACT


Objective To investigate the clinical efficacy, cognitive function and prolactin levels of low-dose olanzapine combined with aripiprazole in the treatment of schizophrenia.

Methods Ninety patients with schizophrenia were randomly divided into two groups, 45 in the study group and 45 in the control group. The control group was treated with aripiprazole. The study group was given a small dose of olanzapine on the basis of the control group. The effects of the two groups on the efficacy, cognitive function and prolactin levels were compared.

Results After treatment, the PANSS score of the study group was significantly lower than that of the control group (P<0.05), and the improvement of cognitive function was better than that of the control group (P<0.05). There was no significant difference in the prolactin level between the study group and the control group(P>0.05).

Conclusion   Low-dose olanzapine combined with aripiprazole in the treatment of schizophrenia can significantly improve the negative and positive status and cognitive function of patients, and has little effect on prolactin levels.

Key words: Olanzapine; aripiprazole; schizophrenia; cognitive function; prolactin

引用本文 / How to Cite This Article

张航雷.小剂量奥氮平联合阿立哌唑对精神分裂症认知功能及催乳素的影响[J]. 国际精神病学杂志, , (): -

参考文献

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