【摘要】

目的 探讨载脂蛋白E（Apolipoprotein E, APOE）基因多态性与精神分裂症发病及认知功能的关联性。
方法 采用PCR-DNA测序法对200例精神分裂症患者和167例健康对照的APOE基因多态性进行检测，采用霍普金斯词语学习测验（Hopkin Verbal Learning Test-Revision ,HVLT-R）、范畴流畅性测验（Category fluency test ,CFT）、Corsi组块测验、连线测验、威斯康星卡片分类测验（Wisconsin Card Sorting Test ,WCST）和持续注意力相同匹配测验（Continuous Performance Test ,CPT-IP）对被试进行认知功能评定。
结果 患者组和对照组APOE基因型频率和等位基因分布频率差异均无统计学意义（P>0.05）。精神分裂症患者中APOE ε2、ε3、ε4等位基因携带组与非携带组之间的HVLT-R、CFT、Corsi组块敲击实验、连线测验、WSCT、CPT-IP测验得分比较，差异没有统计学意义（P>0.05）。
结论 本研究未发现APOE基因多态性与精神分裂症发病及其认知功能有关联性。

【Abstract】

Objective To explore the association between polymorphism of APOE and cognitive function in schizophrenia in Chinese Han population.
Methods Polymorphism of APOE was genotyped by using ABI sequencer in 200 schizophrenic patients and 167 healthy controls. The cognitive function of schizophrenic patients were assessed by using a battery of neuropsychological test, which includes Hopkin Verbal Learning Test-Revision (HVLT-R), category fluency test (CFT), Wisconsin Card Sorting Test (WCST), Corsi Block tapping test, Connections test and Continuous Performance Test (CPT-IP).
Results There were no significant differences in genotype distribution and allelic frequency of APOE between schizophrenia group and control group(P>0.05).Compared with different APOE genotypes schizophrenia, there were no significant differences on cognitive function ( P > 0.05).
Conclusion  s APOE gene polymorphism may not be associated with schizophrenia.