本刊首页 > 期刊目次 > 重复经颅磁刺激联合SSRIs类药物对老年脑卒中后抑郁患者认知功能的临床研究

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重复经颅磁刺激联合SSRIs类药物对老年脑卒中后抑郁患者认知功能的临床研究

  • 余寒

* 通信作者: 余寒, 单位:四川省自贡市精神卫生中心 643000

摘要

[摘要]
目的:探讨重复经颅磁刺激(rTMS)对脑卒中后抑郁患者认知功能的影响。

方法:选择120例脑卒中后抑郁患者,随机分为药物治疗组(n=40例)、药物联合伪刺激治疗组(n=40例)、药物联合rTMS组(n=40例),于治疗前、治疗后第2、4、8周末行P300检测、汉密尔顿抑郁量表(HAMD)、简易智力状态检查量表(MMSE)。

结果:rTMS治疗组,与药物治疗组、伪刺激治疗组在治疗后第2周比较HAMD评分明显下降;治疗第4周比较MESS评分评分明显升高;在治疗后第8周比较P300潜伏期缩短、波幅增加(P<0.05)。

结论:重复经颅磁刺激(rTMS)联合SSRIs类药物治疗脑卒中后抑郁患者能较早改善患者抑郁症状及认知功能。

关键词:[关键词] 脑卒中后抑郁 重复经颅磁刺激 P300电位 认知功能

ABSTRACT

【Abstract】
Objective To explore the efficacy of repetitive transcranial magnetic stimulation in patients with post-stroke depression .

Methods 120 cases of patients with post-stroke depression were divided into drug treatment only group,drug combined with pseudo-stimulation treatment group and drug combined with repetitive transcranial magnetic stimulation group. Forty patients were in each group. P300, the Hamilton depression scale and mini-mental state examination were observed at baseline and after treatment of 2 weeks, 4 weeks and 8 weeks.

Results There were significant decrease of the scores of HAMD in the drug combined with repetitive transcranial magnetic stimulation group than the other two groups(P<0.05). The scores of MMSE in the rTMS group were statistically significant higher than others after treatment of 4 weeks(P<0.05). There were shorter latency and increased amplitude of P300 in the rTMS combined with drug group after treatment of 8 weeks.

Conclusion   The repetitive transcranial magnetic stimulation combined with SSRIs can improve the depressive symptoms and cognitive function in patients with post-stroke in early stage.

Key words: Key words:Post-stroke depression,Repetitive transcranial magnetic stimulation,P300 potentials, Cognitive function

引用本文 / How to Cite This Article

余寒.重复经颅磁刺激联合SSRIs类药物对老年脑卒中后抑郁患者认知功能的临床研究[J]. 国际精神病学杂志, , (): -

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