【摘要】目的 研究H型高血压与脑梗死后认知功能障碍的关系。方法 选择本院2018年1月-2020年1月50例H型高血压合并脑梗死患者为研究对象，选择年龄、性别配对同期入院治疗的50例单纯高血压合并脑梗死以及非高血压脑梗死患者。设为A、B、C三组。比较三组患者血清同型半胱氨酸( Hcy) 水平，采用蒙特利尔认知功能量表( MoCA)评估三组患者认知功能障碍发生率，并比较量表各认知领域的差异。结果 A组血清Hcy水平以及认知功能障碍发生率显著高于B组与C组，差异均有统计学意义(P<0.05)，B组与C组之间比较差异无统计学意义（P>0.05）；A组MoCA量表中延迟回忆、视空间与执行功能、注意力、命名以及MoCA总分等显著低于B组与C组，差异均有统计学意义(P<0.05)，语言、抽象思维、定向力差异无统计学意义（P＞0.05）；B组视空间与执行功能以及MoCA总分显著低于C组，差异均有统计学意义(P<0.05)，。结论 H型高血压合并脑梗死患者认知功能障碍发生率更高，其认知功能损害主要集中在延迟回忆、视空间与执行功能、注意力、命名等方面。
[Abstract] Objective To study the relationship between H-Type hypertension and cognitive dysfunction after cerebral infarction. Methods Fifty patients with H-type hypertension combined cerebral infarction from January 2018 to January 2020 in our hospital were selected as the study subjects. Fifty patients with simple hypertension combined with cerebral infarction and non-hypertensive cerebral infarction were selected by age and gender matching during the same period of admission. They were divided into A, B, C groups. The serum homocysteine (Hcy) levels among three groups of patients were compared. The Montreal Cognitive Function Scale (MoCA) was used to evaluate the incidence of cognitive dysfunction among the three groups of patients. The differences in the cognitive domains of the scale were compared. Results The serum Hcy level and the incidence of cognitive dysfunction in group A were significantly higher than those in group B and group C, the difference was statistically significant (P<0.05). There was no statistically significant difference between group B and group C (P>0.05). The delayed recall, visual space and executive function, attention, nomenclature, and total MoCA scale in the MoCA scale of group A were significantly lower than those of group B and group C, and the differences were statistically significant (P<0.05). Differences in language, abstract thinking, and orientation were not statistically significant (P>0.05). The visual space and executive function of group B and the total score of MoCA were significantly lower than those of group C, the differences were statistically significant (P<0.05). Conclusion Patients with H-type hypertension and cerebral infarction have a higher incidence of cognitive dysfunction, and their cognitive impairment mainly focuses on delayed recall, visual space and executive function, attention, and naming.
引用本文 / How to Cite This Article
成站强.H型高血压与脑梗死后认知功能障碍的关系研究[J]. 国际精神病学杂志, 2020, 47(5): 976-978