本刊首页 > 期刊目次 > 联合药物方案治疗老年难治性精神分裂症疗效及对血清Leptin、神经因子水平的影响

• 文章 •

联合药物方案治疗老年难治性精神分裂症疗效及对血清Leptin、神经因子水平的影响

  • 路广义

* 通信作者: 路广义, 单位:河南省驻马店市第二人民医院老年男性精神科 463000

摘要

【摘要】
目的:探讨联合药物方案治疗老年难治性精神分裂症疗效及对血清Leptin、神经因子水平的影响。

方法:回顾性分析我院2018年1月-2020年1月收治首老年难治性精神分裂症患者共182例临床资料,其中97例采用奥氮平单药治疗(奥氮平组),85例采用齐拉西酮联合奥氮平双药方案治疗(联合组);比较两组临床疗效,治疗前后PANSS量表评分,治疗前后实验室指标水平及安全性指标。

结果:联合组治疗总有效率显著高于奥氮平组(p<0.05);联合组治疗后4周、8周及12周PANSS量表评分均显著低于对照组、治疗前(p<0.05);观察组治疗后12周BDNF、NGF及Leptin水平均显著高于对照组、治疗前(p<0.05);奥氮平组治疗后12周FBG、TC及BMI水平均显著高于治疗前(p<0.05);联合组治疗后12周FBG、TC及BMI水平均显著低于奥氮平组(p<0.05);同时两组治疗前后血常规指标和ECG均正常,均未见其他严重不良反应。

结论:联合药物方案治疗老年难治性精神分裂症具有明显疗效获益优势,且安全性良好;而这一疗效优势可能与该方案能够更为明显上调血清神经因子水平有关。

关键词:齐拉西酮;奥氮平;老年;精神分裂症

ABSTRACT

Abstract:
Objective To investigate the clinical effects of combined drug regimen in the treatment of elderly patients with refractory schizophrenia and influence on the levels of serum leptin and nerve factor.

Methods Clinical data of 182 elderly patients with refractory schizophrenia were retrospectively chosen in the period from January 2018 to January 2020 in our hospital and randomly divided into 2 groups including olanzapine group (97 patients) with olanzapine used alone and combined group (85 patients) with ziprasidone combined with olanzapine; and the clinical efficacy, the PANSS score and laboratory index levels before and after treatment and safety index of 2 groups were compared.

Results The total clinical effects of 2 groups were significantly lower than before treatment(p<0.05).The PANSS score in 4, 8 and 12 weeks after treatment of combined group were significantly less than olanzapine group and before treatment(p<0.05). The levels of BDNF, NGF and Leptin in 12 weeks after treatment of combined group were significantly less than olanzapine group and before treatment(p<0.05). The levels of FBG, TC and BMI in 12 weeks after treatment of olanzapine group were significantly higher than before treatment(p<0.05). The levels of FBG, TC and BMI in 12 weeks after treatment of combined group were significantly lower than olanzapine group(p<0.05). The blood routine indexes and ECG were normal before and after treatment in 2 groups, and other serious adverse reactions were not found.

Conclusion   Combined drug regimen in the treatment of elderly patients with refractory schizophrenia has the advantages in obvious clinicla effects benefit and satisfactroy safety, which may be related to the significantly increased levels of serum nerve factor.

Key words: ziprasidone; olanzapine; elderly; schizophrenia

引用本文 / How to Cite This Article

路广义.联合药物方案治疗老年难治性精神分裂症疗效及对血清Leptin、神经因子水平的影响 [J]. 国际精神病学杂志, , (): -

参考文献

相关文章