本刊首页 > 期刊目次 > 精神分裂症患者伴发代谢综合征的相关因素分析及早期检测超敏C反应蛋白水平的临床意义

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精神分裂症患者伴发代谢综合征的相关因素分析及早期检测超敏C反应蛋白水平的临床意义

  • 崔向波

* 通信作者: 崔向波, 单位:河南省洛阳荣康医院普通精神科,河南洛阳,471000

摘要

[摘要]
目的:探讨精神分裂症患者伴发代谢综合征的相关因素及早期检测超敏C反应蛋白水平(hs-CRP)的临床意义。

方法:选择我院2019年1月~2020年1月诊治的精神分裂症患者139例作为研究对象,统计伴发代谢综合征率,比较不同临床资料的精神分裂症患者伴发代谢综合征率的差异,判定精神分裂症患者伴发代谢综合征的相关因素。按照是否伴发代谢综合征将所有患者分为两组,比较两组患者的血脂及hs-CRP水平。

结果:139例精神分裂症患者伴发代谢综合征率为19.4%(27/139),年龄、体重指数、糖尿病史、高血压史、代谢综合征家族疾病史、病程、服药种类是精神分裂症患者伴发代谢综合征的相关因素(P<0.05)。其中,代谢综合征伴发组27例、不伴发组112例,伴发组患者的三酰甘油(TG)水平显著高于不伴发组、高密度脂蛋白胆固醇(HDL-C)显著低于不伴发组,hs-CRP水平显著高于不伴发组,差异均有统计学意义(P<0.05)。

结论:精神分裂症患者伴发代谢综合征受到年龄、体重指数、糖尿病史、高血压史、代谢综合征家族疾病史、病程、服药种类多种因素影响,应积极采取有效措施,还可以将hs-CRP与血脂水平监测作为参考指标,指导防治工作。

关键词:[关键词] 精神分裂症;代谢综合征;相关因素;超敏C反应蛋白;临床意义

ABSTRACT

[Abstract]
Objective: To investigate the relevant factors for schizophrenia patients with metabolic syndrome and the clinical significance of early detection of hypersensitive C-reactive protein (hs-CRP).

Methods: 139 patients with schizophrenia diagnosed and treated in our hospital from January 2019 to January 2020 were selected as the research object, and the rate of associated metabolic syndrome was counted, the differences in the rates of metabolic syndrome in schizophrenic patients with different clinic data were compared, determined whether the above items are related factors of metabolic syndrome in patients with schizophrenia. All patients were divided into two groups according to whether they were accompanied by metabolic syndrome, and the blood lipids and hs-CRP levels of two groups were compared.

Results: The rate of 139 patients with schizophrenia accompanied by metabolic syndrome was 19.4% (27/139). Univariate and multivariate logistic regression analysis indicated age, body mass index, diabetes history, hypertension history, family disease history, disease course and medication types were the related factors of metabolic syndrome in patients with schizophrenia (P<0.05). Among them, there were 27 cases in the metabolic syndrome accompanying group and 112 cases in the non-associated group, the triglyceride (TG) level of patients in the accompanying group was significantly higher than that in the non-associated group, and the high-density lipoprotein cholesterol (HDL-C) was significantly lower than the unaccompanied group, hs-CRP level was significantly higher than the unaccompanied group, and the differences were statistically significant (P<0.05).

Conclusion  : The metabolic syndrome associated with schizophrenia is affected by various factors such as age, body mass index, diabetes history, hypertension history, family disease history, disease course and medication type. Active measures should be taken and hs-CRP and blood lipid level monitoring can be used as reference indicators to guide the prevention and treatment of metabolic syndrome in patients with schizophrenia.

Key words: [Key words] schizophrenia; metabolic syndrome; relevant factors; hypersensitive C-reactive protein; Clinical significance

引用本文 / How to Cite This Article

崔向波.精神分裂症患者伴发代谢综合征的相关因素分析及早期检测超敏C反应蛋白水平的临床意义[J]. 国际精神病学杂志, , (): -

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