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舒肝解郁胶囊联合阿戈美拉汀治疗肝癌合并抑郁的临床疗效

  • 胡述博

* 通信作者: 胡述博, 单位:驻马店市中心医院

摘要

【摘要】
目的 探讨舒肝解郁胶囊联合阿戈美拉汀治疗肝癌合并抑郁的临床疗效。

方法 选择我院2017年6月至2020年1月108例肝癌合并抑郁患者,数字表法均分为两组,各54例,对照组给予阿戈美拉汀治疗,观察组在此基础上联合服用舒肝解郁胶囊,共治疗8周。比较治疗前后汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠质量指数(PSQI)以及汉密尔顿焦虑量表(HAMA),评价治疗后综合疗效以及治疗期间不良反应发生率。

结果 两组治疗后HAMD评分、PSQI指数、HAMA评分均显著降低,且治疗后观察组三项评分均显著低于对照组,(P<0.05);观察组治疗总有效率显著高于对照组,(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。

结论 肝癌合并抑郁患者采用舒肝解郁胶囊联合阿戈美拉汀治疗能够显著改善焦虑、抑郁情绪以及睡眠质量,提升临床疗效,且不增加不良反应发生率,临床治疗安全有效。

关键词:关键词:舒肝解郁胶囊;阿戈美拉汀;肝癌合并抑郁

ABSTRACT

[Abstract]
Objective To discuss the clinical effect of Shugan Jieyu capsule combined with agomelatine in the treatment of liver cancer with depression.

Methods A total of 108 patients with liver cancer and depression from June 2017 to January 2020 in our hospital were selected. They were divided into two groups by the digital table method, with 54 cases in each group. The control group was given agomelatine, and the observation group took Shugan Jieyu capsules on this basis for 8 weeks. The Hamilton depression scale (HAMD), Pittsburgh sleep quality index (PSQI) and Hamilton anxiety scale (HAMA) were compared before and after treatment. The comprehensive efficacy after treatment and the incidence of adverse reactions during treatment were evaluated.

Results The HAMD score, PSQI index and HAMA score of the two groups were significantly reduced after treatment, and the three scores of the observation group after treatment were significantly lower than the control group (P<0.05). The total effective rate of treatment in the observation group was significantly higher than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).

Conclusion   Patients with liver cancer and depression treated with Shugan Jieyu capsules combined with agomelatine can significantly improve anxiety, depression and sleep quality, improve clinical efficacy, and do not increase the incidence of adverse reactions.

Key words: Key words Shugan Jieyu Capsule; Agomelatine; Liver Cancer with Depression

引用本文 / How to Cite This Article

胡述博.舒肝解郁胶囊联合阿戈美拉汀治疗肝癌合并抑郁的临床疗效[J]. 国际精神病学杂志, 2021, 48(2): 339-342

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