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小剂量氨磺必利对长期住院精神分裂症患者阴性症状及认知功能影响研究

  • 赵虎

* 通信作者: 赵虎, 单位:烟台市莱州荣军医院 261400

摘要

【摘要】
目的 探讨小剂量氨磺必利对长期住院精神分裂症患者阴性症状和认知功能的影响。

方法 将我院住院时间5年以上的78名精神分裂症患者随机分成研究组(39例)和对照组(39例),对研究组在既往治疗的基础上合并小剂量氨磺必利治疗,对照组则在既往治疗基础上合并安慰剂。共治疗8周。在治疗前及治疗8周末分别采用阴性症状量表(SANS)、MATRICS公认认知功能成套测验共识版(MCCB)评定疗效及认知功能。

结果 治疗后研究组阴性症状量表(SANS)评分较研究前显著下降(P<0.05),对照组无显著差异。研究组MCCB的语义流畅(t=-3.272)、连线测验(t=3.018)、数字序列(t=-3.602)、空间广度(t=-3.827)、言语记忆(t=-4.601)、视觉记忆(t=2.357)、情绪管理(t=-4.573)测验成绩与研究前相比差异有统计学意义(P均<0.05)。对照组无显著差异。

结论 对长期住院精神分裂症患者合并使用小剂量氨磺必利能改善其阴性症状及认知功能。

关键词:【关键词】氨磺必利;长期住院精神分裂症;阴性症状;认知功能

ABSTRACT

【 Abstract 】
Objective To investigate the effect of low dose amesulfapil on negative symptoms and cognitive function in long-term hospitalized schizophrenic patients..

Methods A total of 78 patients with schizophrenia who had been hospitalized in our hospital for more than 5 years were randomly divided into study group (39 cases) and control group (39 cases). The study group was treated with low-dose amesulfapil on the basis of previous treatment, while the control group was treated with placebo on the basis of previous treatment.Treatment lasted 8 weeks.The negative Symptom Scale (SANS) and the CONSENSUS version of MATRICS Recognized Cognitive Function Tests (MCCB) were used to evaluate the efficacy and cognitive function before treatment and at the end of treatment 8..

Results After treatment, the negative symptom scale (SANS) score in the study group was significantly reduced compared with that before the study (P < 0.05), and there was no significant difference in the control group.The results of the study group MCCB showed statistically significant differences (P < 0.05) in semantic fluency (T =-3.272), line test (T =3.018), number sequence (t=-3.602), spatial breadth (t=-3.827), verbal memory (T =-4.601), visual memory (T =2.357), and emotional management (t=-4.573).There was no significant difference in the control group.

Conclusion   The negative symptoms and cognitive function of long-term hospitalized schizophrenic patients can be improved by the combination of low dose amesulfapil.

Key words: 【 Key words 】Amisulpride; Long-term hospitalization schizophrenia; Negative symptoms;Cognitive function

引用本文 / How to Cite This Article

赵虎.小剂量氨磺必利对长期住院精神分裂症患者阴性症状及认知功能影响研究[J]. 国际精神病学杂志, , (): -

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