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双相情感障碍抑郁发作治疗后复发的危险因素研究

  • 宫鹏

* 通信作者: 宫鹏, 单位:威海市立第三医院

摘要

摘要
目的:探讨双相情感障碍抑郁发作治疗后复发的危险因素。

方法:研究对象为2017年4月-2019年4月120例双相情感障碍抑郁发作患者,经治疗达痊愈标准后随访1年,记录复发情况,设为复发组与未复发组,比较两组性别、睡眠障碍等临床资料,经单因素、多因素分析治疗后复发的危险因素。

结果:120例患者复发28例,复发率23.33%;复发组与未复发组自杀未遂、学历、合并睡眠障碍、合并焦虑症、既往住院次数、负性生活事件、停药方式差异具有统计学意义(P>0.05);两组性别、发病年龄、婚姻差异无统计学意义(P>0.05);多因素分析显示,合并睡眠障碍、合并焦虑症、既往住院次数>3次、负性生活事件评分>80分、迅速停药是双相情感障碍抑郁发作治疗后复发的危险因素。

结论:双相情感障碍抑郁发作治疗后复发率较高,受到睡眠障碍、焦虑症、负性生活事件等的影响,应就相关危险因素及早采取措施以降低复发率。

关键词:关键词:双相情感障碍;抑郁发作;复发;危险因素

ABSTRACT

[Abstract]
Objective To discuss the risk factors of relapse after treatment of bipolar disorder depression.

Methods A total of 120 patients with depressive episodes of bipolar disorder from April 2017 to April 2019 were the study subjects. After treatment, they who reached the standard of recovery were followed up for 1 year and the relapse was recorded. They were set as the relapse group and the non-relapse group. The clinical data of gender and sleep disorders were compared between the two groups. The risk factors of relapse after treatment were analyzed by single factor and multi-factor analysis.

Results Of the 120 patients, 28 relapsed, with a recurrence rate of 23.33%. There were statistically significant differences between the relapsed group and the non-relapsed group in suicide attempt, education, combined sleep disorder, combined anxiety disorder, previous hospitalizations, negative life events, and withdrawal methods (P>0.05). There was no significant difference in gender, age of onset, and marriage between the two groups (P>0.05). Multivariate analysis showed that combined sleep disorder, combined anxiety disorder, previous hospitalizations> 3 times, negative life event score> 80 points, and rapid drug withdrawal are risk factors for relapse after treatment of bipolar disorder depression episodes.

Conclusion   Bipolar affective disorder has a high recurrence rate after treatment of depression. It is affected by sleep disturbance, anxiety disorder, negative life events, etc., and relevant risk factors should be taken early to reduce the recurrence rate.

Key words: Key words Bipolar Disorder; Depressive Episode; Relapse; Risk Factors

引用本文 / How to Cite This Article

宫鹏.双相情感障碍抑郁发作治疗后复发的危险因素研究[J]. 国际精神病学杂志, 2021, 48(2): 248-250

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