【摘要】

摘要：[目的]观察探讨盐酸多奈哌齐片联合咪达唑仑对老年痴呆合并睡眠障碍患者预后影响。[
方法]于2018年07月至2019年08月，选择130例老年痴呆合并睡眠障碍患者，设为对照组与观察组，对照组（n=65）单用盐酸多奈哌齐片治疗，观察组（n=65）给予盐酸多奈哌齐片+咪达唑仑治疗，评价临床疗效，以观察预后指标。[
结果] 两组在开展治疗前，MMSE评分经评测无统计学差异（P>0.05），在开展治疗后，评测分值均有升高，且观察组更为显著，差异具有统计学意义（P<0.05）。两组在开展治疗前，生活质量评分经评测无统计学差异（P>0.05），在开展治疗后，评测分值均有升高，且观察组更为显著，差异具有统计学意义（P<0.05）。两组患者的睡眠质量比较，观察组治疗后PSQI评分低于对照组（P<0.05）。观察组的总有效率高于对照组，有统计学意义（P<0.05）。［
结论]老年痴呆合并睡眠障碍患者，给予盐酸多奈哌齐片联合咪达唑仑治疗，疗效确切，安全可靠。

【Abstract】

Abstract: [Objective] To observe the effect of quetiapine combined with midazolam on the prognosis of patients with dementia and sleep disorders. [Method] From July 2018 to August 2019, 130 patients with dementia and sleep disorders were selected as the control group and the observation group. The control group (n=65) was treated with quetiapine alone, and the observation group (n =65) Give quetiapine + midazolam to evaluate the clinical efficacy to observe the prognostic indicators. [
Results] After the treatment in the observation group, the pathological efficacy, ie rhythm disorder, behavior disorder, mental disorder, fear anxiety and hallucination scores of the BEHAVE-AD scale were lower than the control group, the difference was statistically significant (P<0.05). Before the treatment, the MMSE scores of the two groups were not statistically different (P>0.05). After the treatment, the evaluation scores increased, and the observation group was more significant, the difference was statistically significant (P<0.05). ). The quality of life scores of the two groups were not statistically different before the treatment (P>0.05). After the treatment, the evaluation scores increased, and the observation group was more significant, the difference was statistically significant (P< 0.05). The sleep quality of the two groups was compared. The PSQI score of the observation group after treatment was lower than that of the control group (P<0.05). The total effective rate of the observation group was higher than that of the control group, which was statistically significant (P<0.05). [
Conclusion  ] Quetiapine combined with midazolam was given to patients with Alzheimer's disease and sleep disorders. The effect is accurate, safe and reliable.