Objective: To discuss and research bronchial tube asthma patients’ whole blood neutrophil and lymphocyte ratio (NLR), blood platelet and lymphocyte ratio(PLR), nitric oxide fraction (FENO) and lung function, and to analyze the relationship between the three factors and the severity of asthma . Methods:A total of 92 patients with bronchial asthma who were in chronic ongoing periods were be included, all of whom were hospitalized between September 2019 and May 2020. These patients are divided into mild asthma(n=27), moderate asthma(n=28), severe asthma(n=37) according to the patient's symptoms and lung function results,the patient's blood routine, nitric oxide fraction as well as the lung function index of correlation are collected use in this experimental study. Results: Three indicators of patients in the asthma (chronic persistent severe) group, namely NLR, PLR, and nitric oxide fraction, were higher than those that of mild and moderate asthma, and there were statistical differences(P<0.05). The NLR was positively correlated with FENO(r=0.395,P<0.05). PLR is positively correlated with FENO(r=0.549,P<0.05). NLR separately with FEV1, FEV1%, FEV1/FVC becomes the inverse correlation(r=-0.460, -0.465, -0.449, P<0.05). PLR separately with FEV1, FEV1%, FEV1/FVC becomes the inverse correlation(r=-0.388, -0.298, -0.276, P<0.05). FENO separately with FEV1, FEV1%, FEV1/FVC becomes the inverse correlation(r=-0.282, -0.249, -0.218, P<0.05). The NLR, PLR, FENO was increased in patients with severe persistent asthma, when NLR>3.48, PLR>156.875, FENO>23, the area of NLR, PLR and FENO under ROC curve was respectively 0.815, 0.750 and 0.780. The area under ROC curve was 0.884 when the three were diagnosed jointly. Conclusion :NLR, PLR and FENO were significantly increased in severe persistent asthma, indicating that these indicators are closely related to the severity of asthma. Combined NLR, PLR and FENO have certain clinical value in the diagnosis and assessment of asthma severity.
Key words: neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio,nitric oxide fraction , lung function, asthma
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于思菁.PLR、NLR及FENO与哮喘严重程度的相关性[J]. 国际精神病学杂志, , (): -