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PLR、NLR及FENO与哮喘严重程度的相关性

  • 于思菁

* 通信作者: 于思菁, 单位:徐州医科大学附属医院呼吸科住院部 221000

摘要


目的:探讨哮喘患者全血中性粒细胞与淋巴细胞的比率(NLR)、血小板计数与淋巴细胞的比率(PLR)、呼出气一氧化氮(FENO)和肺功能,与哮喘严重程度的关系,以对临床实践提供指导。

方法:纳入2019年9月-2020年5月于徐州医科大学附属医院住院就诊的慢性持续期哮喘患者92例,收集患者的血常规、呼出气一氧化氮以及肺功能相关指标,并计算NLR、PLR。根据患者症状及肺功能

结果将其分为轻度(n=27例)、中度(n=28例)、重度(n=37例)3组,比较三组数据差异。

结果:重度持续组患者NLR、PLR以及FENO高于轻度及中度组患者,且存在统计学差异(P<0.05)。血清NLR与FENO呈正相关(r=0.395,P<0.05);PLR与FENO呈正相关(r=0.549,P<0.05);NLR与一秒用力呼气容积(FEV1)、一秒用力呼气容积占预计值百分比(FEV1%)、一秒用力呼气容积/用力肺活量(FEV1/FVC)呈负相关(r=-0.460,-0.465,-0.449,P<0.05),PLR与FEV1、FEV1%、FEV1/FVC呈负相关(r=-0.388,-0.298,-0.276,P<0.05);FENO与FEV1、FEV1%、FEV1/FVC呈负相关(r=-0.282,-0.249,-0.218,P<0.05);重度持续期哮喘患者NLR、PLR、FENO值升高,NLR>3.48、PLR>156.875、FENO>23,在ROC曲线下的面积为0.815,0.750,0.780;三者联合诊断时,在ROC曲线下的面积为0.884;

结论:NLR、PLR、FENO在重度持续期哮喘中明显升高,表明此三项指标与哮喘严重程度密切相关,NLR、PLR及FENO 联合检测对诊断评估哮喘病情轻重有一定的临床价值。

关键词:中性粒细胞与淋巴细胞的比率,血小板计数与淋巴细胞的比率,呼出气一氧化氮,肺功能,哮喘

ABSTRACT


Objective: To discuss and research bronchial tube asthma patients’ whole blood neutrophil and lymphocyte ratio (NLR), blood platelet and lymphocyte ratio(PLR), nitric oxide fraction (FENO) and lung function, and to analyze the relationship between the three factors and the severity of asthma .

Methods:A total of 92 patients with bronchial asthma who were in chronic ongoing periods were be included, all of whom were hospitalized between September 2019 and May 2020. These patients are divided into mild asthma(n=27), moderate asthma(n=28), severe asthma(n=37) according to the patient's symptoms and lung function results,the patient's blood routine, nitric oxide fraction as well as the lung function index of correlation are collected use in this experimental study.

Results: Three indicators of patients in the asthma (chronic persistent severe) group, namely NLR, PLR, and nitric oxide fraction, were higher than those that of mild and moderate asthma, and there were statistical differences(P<0.05). The NLR was positively correlated with FENO(r=0.395,P<0.05). PLR is positively correlated with FENO(r=0.549,P<0.05). NLR separately with FEV1, FEV1%, FEV1/FVC becomes the inverse correlation(r=-0.460, -0.465, -0.449, P<0.05). PLR separately with FEV1, FEV1%, FEV1/FVC becomes the inverse correlation(r=-0.388, -0.298, -0.276, P<0.05). FENO separately with FEV1, FEV1%, FEV1/FVC becomes the inverse correlation(r=-0.282, -0.249, -0.218, P<0.05). The NLR, PLR, FENO was increased in patients with severe persistent asthma, when NLR>3.48, PLR>156.875, FENO>23, the area of NLR, PLR and FENO under ROC curve was respectively 0.815, 0.750 and 0.780. The area under ROC curve was 0.884 when the three were diagnosed jointly.

Conclusion   :NLR, PLR and FENO were significantly increased in severe persistent asthma, indicating that these indicators are closely related to the severity of asthma. Combined NLR, PLR and FENO have certain clinical value in the diagnosis and assessment of asthma severity.

Key words: neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio,nitric oxide fraction , lung function, asthma

引用本文 / How to Cite This Article

于思菁.PLR、NLR及FENO与哮喘严重程度的相关性[J]. 国际精神病学杂志, , (): -

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