【摘要】

目的：评估伴与不伴睡眠障碍的精神分裂症超高危患者的认知功能，探讨睡眠质量对该人群认知功能的影响。
方法：选取精神分裂症超高危患者97例，用匹兹堡睡眠质量指数量表评估睡眠情况，将被试分为伴睡眠障碍组46人，不伴睡眠障碍组51人，采用重复性成套心理测验评估认知功能。
结果：伴有睡眠障碍组在即刻记忆、注意、视觉广度、认知总分上均明显低于不伴睡眠障碍组（P<0.05）。匹兹堡睡眠质量指数与即刻记忆、注意评分，认知总分存在明显的负相关，（r=-0.35，P<0.001; r=-0.39，P=0.001; r=-0.38，P<0.001），而在视觉广度、言语、延迟记忆方面，相关均未有显著的统计学差异，（P>0.05）。
结论：伴睡眠障碍的精神分裂症超高危患者认知功能比不伴睡眠障碍患者组损害更重，睡眠障碍可能加重了超高危患者的认知损害。

【Abstract】

Objective: To investigate differences in cognitive function in patients at ultra-high-risk for psychosis (UHR) with and without sleep disturbances. Method: Totally 97 subjects with ultra-high-risk for psychosis were recruited and assessed with the Repeatable Batter for the Assessment of Neuropsychological Status (RBANS) for cognition function, and Pittsburgh sleep quality index (PSQI) for sleep.
Results: Visual span and cognitive total scores of the UHR group with sleep disorder were significantly lower than UHR group without sleep disorder (P<0.05). The Pittsburgh sleep quality index was negatively correlated with immediate memory, attention, and cognitive scores (r=-0.35, P<0.001; r=-0.39, P= 0.001; r=-0.38, P<0.001), but there were no statistically significant differences in terms of visual breadth, speech and delayed memory (P>0.05).
Conclusion  : Cognitive impairment was more severe in patients at high risk of schizophrenia with sleep disturbance than in patients without sleep disturbance, and sleep disturbance may aggravate cognitive impairment in patients at high risk of schizophrenia.