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边缘型人格障碍表观遗传学研究进展

  • 张芸,赵霏,马静

* 通信作者: 马静, 单位:湖南省脑科医院儿少心理科 410000

摘要

边缘型人格障碍是一种常见的复杂精神障碍,由于其高发生率和严重性已成为精神医学与行为医学界较为关注的一个课题。然而,目前在临床上对边缘型人格障碍的诊断及治疗都较为棘手,这与对其遗传和表观遗传机制认识不清有着很大关系。近年来,国外逐渐开始从表观遗传学角度对边缘型人格障碍的生物学机制进行探讨,并取得一系列研究进展。本文通过PRISMA系统综述,分别从候选基因与全基因组两个方面对国外已有的甲基化研究进行归纳与整理,并指出该领域未来的研究重点与方向。这不仅会进一步有助于我国科研人员加深对边缘型人格障碍生物学机制的理解,同时也会对临床边缘型人格障碍的诊治提供大量有价值的信息。

关键词:边缘型人格障碍;DNA甲基化;表观遗传学;全基因组甲基化

ABSTRACT

Borderline personality disorder (BPD) is a common complex mental disorder. Due to its high prevalence and severity, which has become a hot topic in the field of mental health and behavioral medicine. However, it is still a tricky problem for the clinician to make a correct diagnosis and treatment, owing to the poor understanding of the pathogenesis of the disease. Recently, the exploring of epigenetic mechanism of borderline personality disorder has been carried out gradually in abroad. However, we didn’t pay much attention on this topic around china. By using the method of PRISMA systematic review, the current research progress were summarized and evaluated systematically from candidate genes and whole genome methylation, and the same time, the research domain and following direction in this field were pointed out.

Key words: Borderline Personality disorder; DNA methylation; epigenetic; EWAS

引用本文 / How to Cite This Article

张芸,赵霏,马静.边缘型人格障碍表观遗传学研究进展[J]. 国际精神病学杂志, , (): -

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