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氨磺必利与利培酮治疗精神分裂症的有效性及不良反应发生率研究

  • 王清溪

* 通信作者: 王清溪, 单位:新乡医学院第二附属医院早期干预一科

摘要

【摘要】
目的:探讨精神分裂症临床治疗中应用氨磺必利与利培酮的疗效差异性及安全性。

方法:遴选时段2019年5月-2020年5月内70例精神分裂症患者,根据治疗方式差异设置分组,应用利培酮治疗35例(记作对照组),给予氨磺必利治疗35例(记作观察组),对临床总有效率、精神状态、生活质量、不良反应率、糖脂代谢及催乳素等指标对比分析。

结果:治疗前,2组PANSS评分对比差异不显著(P>0.05),治疗后观察组PANSS评分更低,同时观察组生活质量评分明显更高,临床总有效率更高,较之对照组(P<0.05)。治疗前,2组催乳素、糖脂代谢指标水平组间对比均差异不显著(P>0.05),治疗后,2组较治疗前IR、TG、RBI指标值均升高,且观察组较对照组RBI水平相对低,对比均具有统计学差异(P<0.05),治疗后组间BMI、IR、TG、TC指标水平对比无统计学差异(P>0.05);2组不良反应率对比无统计学差异(P>0.05),且经对症处理均消失。

结论:应用氨磺必利治疗精神分裂症相比利培酮,临床疗效更为显著,可改善患者精神症状,有效提高生活质量,且用药安全性有保证,提高疾病预后。

关键词:关键词:氨磺必利;利培酮;精神分裂症;有效性;不良反应发生率

ABSTRACT

[Abstract]
Objective: To explore the difference and safety of amisulpride and risperidone in the clinical treatment of schizophrenia.

Methods: 70 schizophrenic patients from May 2019 to may 2020 were selected and divided into two groups according to different treatment methods. 35 patients were treated with risperidone (recorded as control group) and 35 patients were treated with amisulpride (recorded as observation group).

Results: before treatment, there was no significant difference in PANSS score between the two groups (P > 0.05). After treatment, the PANSS score of the observation group was lower, the quality of life score of the observation group was significantly higher, and the clinical total effective rate was higher than that of the control group (P < 0.05). Before treatment, there was no significant difference in prolactin, glucose and lipid metabolism indexes between the two groups (P > 0.05). After treatment, the IR, TG and RBI indexes of the two groups were higher than before treatment, and the RBI level of the observation group was lower than that of the control group (P < 0.05). There was no significant difference in BMI, IR, TG and TC indexes between the two groups after treatment (P > 0.05); There was no significant difference in the adverse reaction rate between the two groups (P > 0.05), and it disappeared after symptomatic treatment.

Conclusion  : Compared with risperidone, amisulpride has more significant clinical effect in the treatment of schizophrenia, which can improve the mental symptoms of patients, effectively improve the quality of life, ensure the safety of medication, and improve the prognosis of the disease.

Key words: Key words: amisulpride; Risperidone; Schizophrenia; Effectiveness; Incidence of adverse reactions

引用本文 / How to Cite This Article

王清溪.氨磺必利与利培酮治疗精神分裂症的有效性及不良反应发生率研究[J]. 国际精神病学杂志, , (): -

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