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糖皮质激素与精神症状关系研究

  • 钟古华,廖君兰,廖小凤,王莉

* 通信作者: 钟古华, 单位:江门市第三人民医院

摘要

[摘要]
目的 探讨影响糖皮质激素导致患者精神障碍的因素,为糖皮质激素临床应用提供指导。

方法 选取2012年1月至2015年6月接受糖皮质激素治疗560例患者进行研究,观察患者基本情况与精神障碍发生率的关系。

结果 本研究中精神障碍发生率为23.93%。单因素分析显示,性别、职业、学历、激素应用时间、病情等对精神障碍的发生率均无影响(p>0.05),年龄、性格、激素类型、激素剂量、激素应用时间、BMI等均可影响精神障碍的发生率(p<0.05或0.01)。多因素Logistic分析显示,激素应用时间、激素类型和激素剂量是导致精神障碍的危险因素(p<0.05或0.01)。

结论 糖皮质激素治疗可导致精神障碍,地塞米松、年龄、激素应用时间等是危险因素,应引起临床医生的重视。

关键词:[关键词]糖皮质激素;精神障碍;相关性

ABSTRACT

[Abstract]
Objective To study the influence factor affecting the incidence of mental disorders induced by glucocorticoid, to provide guidance for the clinical application of glucocorticoid.

Methods 560 patients treated with glucocorticoid were selected as objects. The relationship between general conditions and incidence of mental disorders of patients were observed and analysed.

Results The incidence of mental disorders was 23.93% in this study. Univariate analysis showed that gender, occupation, education, hormone application time and severity of illness on the incidence of mental disorders had no effect (P > 0.05). Multivariate Logistic analysis showed that the hormone application time, hormone type and steroid dose are risk factors leading to mental disorder (P < 0.05 or 0.01).

Conclusion   Glucocorticoid treatment can lead to mental disorders, dexamethasone, age, hormone application time are risk factors, which should cause clinician to take seriously.

Key words: [Key Words]Glucocorticoid; Mental Disorder; Correlation

引用本文 / How to Cite This Article

钟古华,廖君兰,廖小凤,王莉.糖皮质激素与精神症状关系研究[J]. 国际精神病学杂志, 2016, 43(5): 809-812

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