本刊首页 > 期刊目次 > 吲达帕胺与氨氯地平联用对高血压合并冠心病患者疗效及血脂水平的影响

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吲达帕胺与氨氯地平联用对高血压合并冠心病患者疗效及血脂水平的影响

  • 许浩

* 通信作者: 许浩, 单位:湖北医药学院附属东风医院 东风总医院心脏中心 442008

摘要


目的:研究吲达帕胺与氨氯地平联用对高血压合并冠心病患者疗效及血脂水平的影响。

方法:选择2015年1月至2015年12月在医院诊治的高血压合并冠心病患者,共148例纳入本次研究。根据随机数字表法将患者划分成观察组以及对照组各74例,对照组用硝苯地平控释片,观察组用苯磺酸氨氯地平片以及吲达帕胺缓释片治疗,两组均治疗6周后比较疗效及实验室指标水平。

结果:两组治疗前后的IgA、IgM及IgG指标水平对比,差异均无统计学意义(P>0.05)。观察组的总有效率是98.65%(73/74),明显高于对照组的89.19%(66/74),差异具有统计学意义(P<0.05)。治疗后两组的DBP、SBP、TC、TG及LDL-C水平分别较各组治疗前明显降低,HDL-C水平分别较各组治疗前明显升高,差异有统计学意义(P<0.05)。治疗后观察组的DBP、SBP、TC、TG及LDL-C水平分别较对照组明显降低,HDL-C水平较对照组明显升高,差异具有统计学意义(P<0.05)。观察组不良反应的总发生率是4.05%(3/74),与对照组的6.76%(5/74)相比,差异无统计学意义(P>0.05)。

结论:联合应用吲达帕胺以及氨氯地平能够有效提升高血压合并冠心病者的临床疗效,并可有效改善其血脂水平,值得予以推广。

关键词:吲达帕胺;氨氯地平;高血压;冠心病;血脂水平

ABSTRACT


Objective: To study effects and blood lipid level of indapamide combined with amlodipine in the treatment of patients with hypertension and coronary heart disease.

Methods: 148 cases of hypertension complicated with coronary heart disease were enrolled in this study from January 2015 to December 2015 in the hospital. According to the random number table, the patients were divided into observation group and control group, each of 74 cases, the control group received Nifedipine Controlled Release Tablets, The observation group received treatment of Amlodipine Besylate Tablets and Indapamide Sustained Release Tablets, two groups were treated for 6 weeks after the comparison of curative effect and the level of laboratory indicators.

Results: The two groups before and after treatment of IgA, IgM and IgG indicators of the level of contrast, the difference was not statistically significant (all P > 0.05). The total effective rate of the observation group was 98.65% (73/74), was significantly higher than the control group of 89.19% (66/74), the difference was statistically significant (P < 0.05). After treatment, the levels of DBP, SBP, TC, TG and LDL-C in the two groups were significantly lower than those before treatment, HDL-C levels were significantly higher than before treatment, the difference was statistically significant (P < 0.05). After treatment, the levels of DBP, SBP, TC, TG, LDL-C and in the observation group were significantly lower than those in the control group, HDL-C level was significantly higher than the control group, the difference was statistically significant (P < 0.05). The total incidence of adverse reactions in the observation group was 4.05% (3/74), compared with the control group of 6.76% (5/74), the difference was not statistically significant (P > 0.05).

Conclusion  : Combined with indapamide and amlodipine besylate can effectively enhance the hypertension and coronary heart disease of clinical curative effect, and can effectively improve the blood lipid level, should be promoted.

Key words: indapamide; amlodipine; hypertension; coronary heart disease; curative effect; blood lipid level

引用本文 / How to Cite This Article

许浩.吲达帕胺与氨氯地平联用对高血压合并冠心病患者疗效及血脂水平的影响[J]. 国际精神病学杂志, , (): -

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