【摘要】

【摘要】目的：探讨帕金森病（PD）外周血促炎症物质与疲劳、焦虑、抑郁、睡眠障碍间的关系。
方法：择取已经确诊的83例PD患者作为研究组，同时择取80例健康者作为对照组。检测上述研究对象外周血促炎物质[IL-6(白细胞介素-6)、IL-1β(白细胞介素-1β)、SIL-2R（血清可溶性白介素2受体）、TNF-α（肿瘤坏死因子-α）、hs-CRP（超敏C反应蛋白）]的分泌水平，采用疲劳量表FS-14、汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）、匹兹堡睡眠质量指数量表（PSQI）对两组研究对象进行疲劳、焦虑、抑郁、睡眠障碍症状的分析评定，并探讨PD外周血促炎症物质与上述症状的关系。
结果：①与对照组比较，研究组患者中IL-6、IL-1β、SIL-2R、TNF-α、hs-CRP的含量水平均明显升高；②研究组患者的FS-14疲劳量表、HAMA、HAMD、PSQI的评分分值均显著升高；③SIL-2R与HAMA、HAMD呈正相关，与FS-14疲劳量表、PSQI无相关性；hs-CRP与HAMA、HAMD呈负相关，与FS-14疲劳量表、PSQI无相关性；而其他促炎物质与疲劳、焦虑、抑郁、睡眠障碍均无相关性。
结论：hs-CRP和SIL-2R与PD病人的抑郁、焦虑评分有显著的相关性，与疲劳、睡眠障碍无相关性；而其他促炎物质与疲劳、焦虑、抑郁、睡眠障碍均无相关性。

【Abstract】

【Abstract】Objective: Discussion of Parkinson's disease relationship between peripheral pro-inflammatory substances and fatigue, anxiety, depression, sleep disorders among.
Methods:Choosing 83 patients as the study group, while those who choose to take 80 cases of healthy control group. Detecting the study of peripheral blood pro-inflammatory substances,including IL-6、IL-1β、SIL-2R、TNF-α、hs-CRP.Using Fatigue Scale FS-14, HAMA,HAMD,PSQI for the two groups were fatigue, anxiety, depression, sleep disorders symptoms analysis and evaluation, and to explore the relationship between PD and peripheral pro-inflammatory substances between the above symptoms.
Results:①Compared with the control group, the study group patients, IL-6, IL-1β, SIL-2R, TNF-α, hs-CRP were significantly higher content of water；②Study group of patients with FS-14 fatigue scale, HAMA, HAMD, PSQI score scores were significantly higher；③SIL-2R and HAMA, HAMD was positively correlated with the FS-14 fatigue scale, PSQI no correlation; hs-CRP and HAMA, HAMD was negatively correlated with the FS-14 fatigue scale, PSQI no correlation; and other pro inflammatory substance with fatigue, anxiety, depression, sleep disorders were not correlated.
Conclusion  s:hs-CRP and SIL-2R in patients with PD depression, anxiety scores were significantly correlated with fatigue, sleep disturbances no correlation; and other pro-inflammatory substances with fatigue, anxiety, depression, sleep disorders were not correlated.