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山东沿海地区人群血尿酸与血压水平的关联研究

  • 尤文君,王杰,陈颖,车奎,王颜刚

* 通信作者: 尤文君, 单位:济宁市第一人民医院内分泌科

摘要

摘要
目的 探讨沿海地区人群血尿酸水平与血压水平的相关性。

方法 根据流行病学抽样调查基本原则,对山东省沿海地区常住居民进行调查。调查内容包括问卷调查、体格检查(身高、体重、腰围、臀围、心率、血压等),实验室检查(肝功能、肾功能、血脂、血糖)等。采用t检验、卡方检验及多因素有序分类logistics回归等分析

方法,对不同性别人群间高血压及高尿酸血症的患病率、不同尿酸水平的人群血压的分布及不同性别、尿酸水平与血压水平的关联进行分析。

结果共调查3157例(男1215人;女1942人),总人群高血压患病率为57.43%;其中男性患病率是64.52%, 女性患病率是52.99%。在男性中,高血压病2级及3级的患病率随尿酸的升高而呈现上升的趋势;女性中,随尿酸水平的升高,各级高血压病发病率呈逐渐上升趋势。logistic 回归分析

结果显示当尿酸水平在第三分位及第四分位时,即尿酸水平>308umol/L时,高血压病前期的患病风险升高,且当尿酸水平在308-371umol/L时,高血压病前期患病风险最高;而当尿酸水平>257umol/L时,高血压病1级、2级和3级患病的危险性增加,且随着尿酸水平的升高,高血压病2级和3级的患病风险随之升高,呈现剂量-反应关系。

结论 血尿酸水平与高血压水平相关,高血压水平及高血压患病风险随尿酸水平的升高而升高。

关键词:关键词:血尿酸; 高尿酸血症; 血压水平; 高血压

ABSTRACT

Abstract:
Objective: To investigate the correlation between the serum uric acid and blood pressure in the people over the age of 30 in Shandong coastal areas;

Methods: According to epidemiological sampling survey of the basic principles, adopting cluster, stratified sampling and simple random sampling method to carry on the sample investigation on permanent residents in Shandong coastal areas. Survey content includes questionnaire, physical examination (height, weight, waist circumference, hip circumference, heart rate, blood pressure, etc.), laboratory examination, routine biochemical examination just like blood glucose, etc. T test, chi square test and multiple factor and ordinal logistics regression analysis were used to analyze the prevalence of hyperuricemia in different gender,  distribution of blood pressure in different levels of uric acid and the correlation between different gender, uric acid level and blood pressure level. different levels of uric acid and blood pressure. 

Results: The survey content 3157 cases (male 1215, female 1942); Total population prevalence was 57.43%; the prevalence of men was 64.52%, the prevalence of female was 52.99%. In the male, the 2 levels of hypertension and 3 levels of hypertension increased with the increase of uric acid level, and in the female, the incidence rate of hypertension increased with the increase of uric acid level. When uric acid level was higher than 257umol/L, the risk of hypertension was increased, and it was also increased with the increase of uric acid level, which was related to the 2 levels and 3 levels. 

Conclusion  : Serum uric acid level was associated with hypertension, and the prevalence of hypertension and blood pressure level increased with the increase of uric acid.

Key words:  Key words: Serum uric acid; Hyperuricemia; Blood pressure level; Hypertension

引用本文 / How to Cite This Article

尤文君,王杰,陈颖,车奎,王颜刚.山东沿海地区人群血尿酸与血压水平的关联研究[J]. 国际精神病学杂志, 2016, 33(6): 1059-1062

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