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精神分裂患者的认知能力与其体内血清同型半胱氨酸水平的关联

  • 邓晶

* 通信作者: 邓晶, 单位:

摘要


目的:探讨体内血清同型半胱氨酸( homocysteine,Hcy)水平与精神分裂症患者的认知能力之间的关系。

方法:选取112例精神分裂症患者做实验组,100例健康志愿者做对照组。比较两组血清 Hcy 水平,高同型半胱氨酸 ( HHcy) 检出率。对实验组进行阳性与阴性症状量表(Positive and Negative Symptoms Scale ,PANSS )评价患者精神状况。采用威斯康星卡片(Wisconsin Card Sorting Test, WCST)、精神分裂症认知功能测试共识版(MATRICS Consensus Cognitive in Schizophrenia, MCCB)评价实验组患者中HHcy患者与非HHcy患者的认知能力。

结果:实验组血浆同型半胱氨酸水平明显高于对照组,差异有统计学意义(P<0. 01)。实验组HHcy率为34.82%,而对照组为7.00%,差异明显(P<0. 01)。两组VB12水平对比,实验组(450.23±124.88)pg /mL 明显低于对照组(302.49±148.19)pg /mL ,差异有统计学意义(P<0. 05)。而叶酸水平则无显著差异,(P>0.05)。实验组中HHcy的MCCB评分总分为(89.22±3.06)分,而非HHcy 总分为(96.11±2.74)分,差异有统计学意义(P<0. 05)。对各组 WCST 完成分类数、正确应答数、错误应答数、持续性应答、非持续性应答等各项分值进行比较,HHcy的完成分类数、正确应答数均明显低于非HHcy患者,差异有统计学意义(P<0. 05)。而余下三项HHcy患者则明显高于非HHcy,差异有统计学意义(P<0. 05)。

结论:血清Hcy 升高可作为精神分裂症的实验室辅助诊断指标之一。

关键词:精神分裂症;同型半胱氨酸;认知能力

ABSTRACT

Abstract:
Objective:To detect the serum homocysteine ( Hcy) level in patients with episode schizophrenia,and to analyze the relationship between serum Hcy levels and episode schizophrenia.

Methods:112 hospitalized patients with episode schizophrenia in our hospital and 100 cases healthy people were used as observation group and control group. The detection rate of high homocysteine septicemia( HHcy) and serum Hcy level were compared between observation group and control group. Psychiatric symptoms were assessed by the total score of positive and negative syndrome scale ( PANSS).The relationship between serum Hcy level and symptoms of episode schizophrenia was analyzed.Cognitive function was assessed by Wisconsion Card Sorting Test(WSCT) and MATRICS Consensus Cognitive in Schizophrenia (MCCB). Results:The serum Hcy level in observation group was significantly higher than that in control group ( P<0.01).The detection rate of HHcy in observation group(34.82%) was significantly higher than that in control group(7.00%) ,(P<0.01) . The serum VB12 level in control group[(302.49±148.19)pg /mL] was significantly higher than that in observation group [(450.23±124.88)pg /mL ], ( P<0.05). The level of folic acid in these groups has no statistically significant.,( P>0.05). By comparing The total scores of MCCB of different Hcy level in observation group , HHcy(89.22±3.06)is significantly lower than non-Hcy (96.11±2.74),( P <0.05) .By comparing scores of WCST ,Cc,Rc significantly increased in the non-HHcy group than those in the HHcy group,Re, Rp ,nRp decreased significantly( P <0.05) .

Conclusion  :The detection rate of HHcy and serum Hcy levels were higher in patients with episode schizophrenia.It has a closely relationship between schizophrenia symptoms and serum Hcy level.

Key words: Episode schizophrenia; Homocysteine;Cognitive function

引用本文 / How to Cite This Article

邓晶.精神分裂患者的认知能力与其体内血清同型半胱氨酸水平的关联[J]. 国际精神病学杂志, 2018, 45(1): 36-38

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