【摘要】

目的 探讨睡眠障碍对重性抑郁障碍患者生存质量的影响。
方法 采用二阶段的调查设计，首先用医院焦虑抑郁量表筛查情绪障碍患者，总分≥8分者再接受诊断评估及睡眠质量、抑郁严重程度、社会支持、人格特征和生存质量的评估。最终667例纳入分析。
结果 匹兹堡睡眠质量量表总分≥7分者454人（68.07%），有睡眠障碍较无睡眠障碍者在生理和心理领域生存质量更差（P分别为0.012，0.006），控制其他混杂变量后，睡眠障碍仍与此两个领域的生存质量负相关。
结论 睡眠障碍可能为重性抑郁障碍患者低生存质量的危险因素。

【Abstract】

Objective To explore the influence of sleep disturbance (SD) on quality of life (QOL) in patients with major depressive disorder (MDD).
Methods This was a cross-sectional study including two steps. First, the patients with mood disorders were screened with Hospital Anxiety and Depression Scale (HADS), those with a total HADS scores ≥8 were interviewed according to DSM-IV, patients diagnosed MDD were further assessed for their sleep quality, severity of symptom, social support, personality characteristic and QOL. 667 patients were diagnosed with MDD. The severity of depression, social support, personality characteristics, sleep quality and QOL of these subjects were assessed with relevant scales.
Results 454 participants (68.07%) were classified into the SD group defined by Pittsburgh Sleep Quality Index (PSQI) total score ≥7, and compared to patients without SD, those with SD scored lower in physical and psychological QOL domains. SD remained significantly negative correlation with poor QOL according to multiple linear regression analyses.
Conclusion   SD may be one of the risk factors of poor QOL in patients with MDD.