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中国人群帕金森病相关因素meta分析

  • 任思思

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摘要

[摘要]
目的:探讨中国人群帕金森病发病的相关因素。

方法:通过中国生物医学文献数据库、万方数据库、维普数据库、中国知网、Pubmed等收集1993-2016年发表的关于帕金森病发表危险因素的相关文献,运用Stata11.0 中Meta-analysis模块对文献进行统计分析。

结果:共纳入15篇文献(病例:对照=1373:1912)。吸烟(OR=0.58,95%CI:0.53-0.62)、喝茶(OR=0.12,95%CI:0.07-0.16)、饮酒(OR=0.70,95%CI:0.46-0.93)、饮用井水(OR=0.33,95%CI:0.17-0.49)为帕金森病的保护因素,家族史(OR=5.13,95%CI:1.73-8.52)、杀虫剂(OR=2.89,95%CI:1.66-4.12)、重大精神创伤(OR=3.28,95%CI:1.69-4.86)是帕金森的危险因素,而抑郁(OR=3.38,95%CI:0.50-6.26)与帕金森无明显相关性。

结论:吸烟、喝茶、饮酒、饮用井水在本研究中为帕金森的保护因素,家族史、杀虫剂、重大精神创伤是帕金森的危险因素,而抑郁尚不能视为帕金森病的相关因素。

关键词: [关键词] 帕金森病;危险因素;相关因素;中国;meta分析

ABSTRACT

[Abstract]
Objective: To study the related factors for Parkinson’s disease (PD) in Chinese population in 1993-2016 that were search from China Biomedical Document Database (CBM), Wangfang Data, VIP Database for Chinese Technical Periodicals (VIP), China Knowledge Resource Integrated Database (CNKI), PubMed.

Methods: A meta-analysis was performed with Stata11.0 for the papers on the related factors for Parkinson’s disease in Chinese population.

Results Fifteen case-control papers including 1,373 cases of Parkinson’s disease and 1912 controls were searched. Smoking(OR=0.58,95%CI:0.53-0.62), tea ingestion(OR=0.12,95%CI:0.07-0.16), alcohol drinking(OR=0.70,95%CI:0.46-0.93), drinking water from well(OR=0.33,95%CI:0.17-0.49)were protective factors of PD.Family history(OR=5.13,95%CI:1.73-8.52),pesticide(OR=2.89,95%CI:1.66-4.12),negative life events(OR=3.28,95%CI:1.69-4.86)were risk factors of PD, and history of depression(OR=3.38,95%CI:0.50-6.26)was not related factor of PD.

Conclusion  :It suggests that smoking, tea ingestion, alcohol drinking, drinking water from well are protective factors of PD. Family history, pesticide, negative life events are risk factors of PD, and history of depression has not been considered a related factor for PD.

Key words: [Key words] Parkinson’s disease; risk factors; related factors; China; Meta analysis

引用本文 / How to Cite This Article

任思思.中国人群帕金森病相关因素meta分析[J]. 国际精神病学杂志, , (): -

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