本刊首页 > 期刊目次 > 氯吡格雷联合依达拉奉对急性脑梗塞血浆内皮素及血清炎症因子的影响

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氯吡格雷联合依达拉奉对急性脑梗塞血浆内皮素及血清炎症因子的影响

  • 周毅,田学成

* 通信作者: 田学成, 单位:湖北省医药学院附属人民医院神经外科

摘要

【摘要】
目的 探讨氯吡格雷与依达拉奉联合治疗急性脑梗塞(ACI)的临床疗效及其对患者血浆内皮素(ET)、血清炎症因子的影响。

方法 将124例ACI患者随机分为2组:观察组(n=62)采用氯吡格雷联合依达拉奉治疗,对照组(n=62)单用氯吡格雷治疗。治疗前及治疗14d后,测定2组的血浆内皮功能指标(ET-1、NO)、血清炎症因子(CRP、IL-6、IL-8、IL-10),比较2组的临床疗效、神经功能缺损评分(NIHSS)及日常生活活动能力(ADL)评分。

结果 观察组总有效率为95.16%,高于对照组的79.03%(P<0.05);治疗14d后,观察组的NIHSS评分显著低于治疗前及对照组(P<0.05),ADL评分显著高于治疗前及对照组(P<0.05);治疗14d后,观察组的血浆ET-1显著低于治疗前及对照组,而NO显著高于治疗前及对照组(P<0.05);治疗14d后,观察组的血清CRP、IL-6、IL-8、IL-10显著低于治疗前及对照组(P<0.05)。

结论 氯吡格雷与依达拉奉联合治疗ACI疗效确切,较单药应用能够增强ADL并改善神经功能缺损,可能与改善血管内皮功能及下调血清炎症因子表达有关。

关键词:【关键词】急性脑梗塞;氯吡格雷;依达拉奉;内皮素;炎症因子

ABSTRACT

Abstract
Objective To evaluate the clinical efficacy and effect on endothelin and serum inflammatory factors of clopidogrel combined with edaravone in patients with acute cerebral infarction (ACI).

Methods A total of 124 patients with ACI were selected and randomly divided into 2 group:The patients in observation group (n=62) were treated with clopidogrel and edaravone, patients in control group (n=62) were treated with clopidogrel.The levels of plasma indicators of endothelial function (ET, NO) and serum inflammatory factors (CRP, IL-6, IL-8, IL-10) between the 2 groups were detected at before and 14d after treatment,and the clinical efficacy, National Institute of Health stroke scale(NIHSS) score and Activities of Daily Living (ADL) score between the two groups were compared.

Results The total effective rate in observation group was 95.16%, higher than 79.03% in the control (P<0.05); 14d after treatment, the NIHSS score in observation group was significantly lower than before treatment and control group (P<0.05), ADL score was significantly higher (P<0.05); 14d after treatment, the plasma ET-1 in observation group was significantly lower than before treatment and control group, and NO was significantly higher (P<0.05); 14d after treatment,the levels of serum CRP, IL-6, IL-8, IL-10 in observation group were significantly lower than before treatment and control group (P<0.05).

Conclusion   The combination therapy of clopidogrel and edaravone for ACI has exact effect, it may be associated with improving endothelial function and decreasing the expression of serum inflammatory factors.

Key words: Key words Acute cerebral infarction; Clopidogrel; Edaravone; Endothelin; Inflammatory cytokines

引用本文 / How to Cite This Article

周毅,田学成.氯吡格雷联合依达拉奉对急性脑梗塞血浆内皮素及血清炎症因子的影响[J]. 国际精神病学杂志, 2017, 34(6): 869-872

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