本刊首页 > 期刊目次 > 小柴胡汤改善对抑郁症状患者的疗效及脑内相关神经递质与神经营养因子分析

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小柴胡汤改善对抑郁症状患者的疗效及脑内相关神经递质与神经营养因子分析

  • 王东明,刘琳琳,孙平,万好

* 通信作者: 王东明, 单位:青岛市精神卫生中心老年二科

摘要


目的 探索小柴胡汤对1中郁症状患者的疗效及脑内神经递质、 神经营养因子变化关系。

方法 选取2013年4月~2015年4月于我院治疗的j中郁症状患者共计96例进行研究。按照入院顺序分为观察组和对照组, 观察组患者应用小柴胡汤进行治疗, 对照组患者应用西药进行治疗 。 观察两组患者治疗后的临床疗效及脑内神经递质、 神经营养因子的变化。

结果 在接受治疗后, 观察组患者的临床疗效显著, 其总有效率达87. 5%, 明显高于对照组治疗后的总有效率41. 67%, 两纽比较差弄具有统计学意义(P<0. 05) 。 两组患者在接受治疗后均出现不同情况的副作用,但是观蔡组的不良反应发生率(4. 17%) 明显少于对照组的不良反应发生率(58. 33%) , 两组比较差异具有统计学意义 (P<0. 05) ; 患者在应用小柴胡汤治疗后, 两组患者的 Ach、5- HT、 NE及 DA值在治疗前后差异具统计学意义(P<0.05) ,且在5-HT、 NE及 DA值方面,观察组较对照组变化更显著, 在 Ach上, 两组患者治疗效果无显著统计学差异 (P>0. 05) ; 两组患者治疗前后神经营养因子变化情况差异具有统计学意义 ( P<0. 05 ) , 观察组患者的神经营养因子的变化较对照组更大。

结论 小柴胡汤治疗抑郁症状的临床疗效显著, 有抗抑郁作用, 并对脑内神经递质、 神经营养因子有一定的影响。

关键词:小柴胡汤; 脑内神经递质; 神经营养因子; 临床疗效

ABSTRACT

〇bjective To analyze Xiaochaihutang efficacy and the changes of related neurotransmitters, neu_ rotrophic factor in patients with depression.

Methods 96 cases with depression symptoms in our hospital were se- lected from April 2013 to April 2015. According to their admission orders, they were divided into the observation group and the control group. The patients in the observation group were treated by Xiaochaihutang, and control group patients were given wesLern medician. Clinical efficacy, changes of brain neurotransmitters, and neurotrophic factor were observed before and after treatment.

Results After treatment, the total effective rate of patients in obsevation group87.5%, was significantly higher than the control group41.67% (P<0.05). Both of two groups have side effects, while the side effects in observation group was4. 17%, it was statistically significantly less than the58. 33% of the control group (P<0.05). With the application of Xiaochaihutang, on Ach, 5-HT, NE and DA values, both groups of paLients has significantly improved aloL compared with those before treatment(P<0.05) , and on5-HT, NE and DA value terms, the observation group has a better effect than the control group, about Ach, there was no statistically significant differences between two groups (P>0.05). The difference about neurotrophic factor of two groups of patients before and after the treatment were statistically significant(P<0.05) , and the observation group has a better effect than the control group.

Conclusion   Xiaochaihutang can improve depression sympotoms, and reg-can improve depression sympotoms, and regulate the neurotransmitters and neurotrophic factors.

Key words: Xiaochaihutang; Brain neurotransmitters; Neurotrophic factor

引用本文 / How to Cite This Article

王东明,刘琳琳,孙平,万好.小柴胡汤改善对抑郁症状患者的疗效及脑内相关神经递质与神经营养因子分析[J]. 国际精神病学杂志, 2016, 43(1): 100-103

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