本刊首页 > 期刊目次 > 氨磺必利对首发精神分裂症患者的疗效及对认知功能改善效果分析

• 文章 •

氨磺必利对首发精神分裂症患者的疗效及对认知功能改善效果分析

  • 孙兵,黄丽娟

* 通信作者: 黄丽娟, 单位:湖北省黄石市下陆区肖铺路2号黄石市精神病医院

摘要

摘要:
目的 探讨氨磺必利用于首发精神分裂症患者中疗效,并观察其对患者认知功能的影响。

方法 将本院78例诊断为首发精神分裂症患者按照随机抛硬币法分为对照组(奥氮平)与治疗组(奥氮平联合氨磺必利),各39例。分别于治疗前、治疗8周后采用阳性症状与阴性症状量表(PANSS)、威斯康星卡片分类测验(WCST)及韦氏记忆量表(WMS)评价患者其临床症状及认知功能改善情况;统计两组临床疗效及不良反应。

结果 治疗8周后,两组患者阳性症状评分、阴性症状评分、一般精神病理症状评分及总分明显低于治疗前,治疗组各项评分均明显低于对照组,P<0.05;两组患者治疗后WCST评分(正确数、完成分类数、随机错误数及持续错误数)、WMS评分较治疗前明显改善,且治疗组各项评分改善程度优于对照组,P<0.05。治疗组治疗总有效率92.31%,明显高于对照组69.23%,P<0.05;治疗期间无严重性不良反应发生。

结论 氨磺必利辅助治疗首发精神分裂症可有效改善患者临床症状及认知功能,同时具有一定安全性,因此值得推荐为首发精神分裂症临床治疗首选药物。

关键词:关键词:首发精神分裂症;氨磺必利;奥氮平;认知功能;阳性症状;阴性症状

ABSTRACT

Abstract:objective To explore the effect of amiosulpride on patients with schizophrenia, and to observe its effect on cognitive function.

Methods 78 patients with schizophrenia were randomly divided into control group (olanzapine) and treatment group (olanzapine combined with amiosulide) in 39 cases. The clinical symptoms and cognitive function of the patients were evaluated by PANSS, WCST and WMS before and 8 weeks after treatment, and the results were statistically analyzed. Two groups of clinical efficacy and adverse reactions.

Results After 8 weeks of treatment, the scores of positive symptom score, negative symptom score, general psychopathological symptom score and total score of the two groups were significantly lower than those of the control group before treatment, P <0.05; WMS score improved significantly after treatment, and the improvement of the score of the treatment group was better than that of the control group, P <0.05. The total effective rate of the treatment group was 92.31%, which was significantly higher than that of the control group (69.23%, P <0.05). No serious adverse reaction occurred during the treatment.

Conclusion   Amosulpride adjuvant treatment of first-episode schizophrenia can effectively improve the clinical symptoms and cognitive function, while a certain degree of safety, it should be recommended as the first choice for clinical treatment of schizophrenia drugs.

Key words: Keywords:First-episode schizophrenia;Amisulpride;Olanzapine;Cognitive function;Positive symptoms;Negative symptoms

引用本文 / How to Cite This Article

孙兵,黄丽娟.氨磺必利对首发精神分裂症患者的疗效及对认知功能改善效果分析[J]. 国际精神病学杂志, 2017, 44(5): 790-793

参考文献

相关文章