【摘要】

目的：比较氯氮平、利培酮、齐拉西酮对精神分裂症首发患者代谢的影响，为临床用药提供合理的参考依据。
方法：依据入组标准和排除标准选取92例我院2013年7月到2015年7月住院患者平均分为三组，分别给用氯氮平、利培酮、齐拉西酮治疗观察12周。
结果：氯氮平组的患者从治疗第4周体质量已显著增加，治疗第8、12周差异均有统计学意义（P＜0.01）。利培酮组第8、12 周与治疗前比较出现差异差异均有统计学意义（P＜0.05），而齐拉西酮组治疗前后体质量变化差异无统计学意义（P＞0.05）。氯氮平组血糖、TG 和 TC 治疗前后比较差异均有统计学意义（P＜0.05 或 P＜0.01）。利培酮组仅在治疗的第12周出 现TG增高，与治疗前比较差异有统计学意义（P＜0.05）。利培酮组血糖、TC，齐拉西酮组血糖、TG和TC与治疗前比较差异均无统计学意义。
结论：3 种抗精神病药对代谢的影响有显著。差异氯氮平组对体质量、糖脂代谢的影响最明显，利培酮组次之，齐拉西酮组对体质量、血糖、血脂无明显影响。

【Abstract】

Objective: comparison of clozapine, risperidone and ziprasidone on mental division first symptom of patients with the metabolic effects, provide a reasonable reference for clinical medication.
Methods: according to inclusion criteria and exclusion criteria selected 92 cases in our hospital in July 2013 to 2015 July hospitalized patients were divided into three groups, respectively, to clozapine, risperidone and ziprasidone in the treatment of observation for 12 weeks.
Results: the quality of the patients in the treatment group was significantly increased from eighth weeks to 12 weeks, and the difference was statistically significant (P < 0.01). Risperidone group at 8 and 12 weeks before and after treatment compared with the differences in differences were statistically significant (P < 0.05), and ziprasidone in the treatment group before and after the change of body weight differences no statistical significance (P > 0.05). There were significant differences in blood glucose, TG and TC before and after treatment in clozapine group (P < 0.05 or P < 0.01). The risperidone group only in the treatment of twelfth weeks of TG increased, compared with before treatment, the difference was statistically significant (P < 0.05). Risperidone group of blood glucose, blood glucose, TC, TG and TC in ziprasidone group and before treatment showed no significant difference.
Conclusion  : the effect of 3 kinds of antipsychotic drugs on metabolism is significant. Differences in clozapine group had marked effect on body weight and lipid metabolism, risperidone group ziprasidone group on body weight, blood glucose, blood lipids, no obvious effect.