目的 探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗对孤独谱系障碍(autism spectrum disorder,ASD)患者事件相关电位(event-related potential,ERP)的影响。方法 21例年龄为(7.91±1.55)岁的ASD患者入组后接受rTMS治疗和康复训练,治疗前及治疗12周进行ERP测试,及完成心理教育评定量表中文修订版(Chinese version of psycho-education profile-revised,C-PEP)评估。结果 ASD患者在治疗后P300、N400 潜伏期缩短、波幅增高 (P<0.05),与治疗前相比较,C-PEP总分和各分量表分的提高有统计学意义(P<0.05);ASD患者ERP 变化与C-PEP总分、口语认知分、认知表现分的变化均无相关(P>0.05)。结论 rTMS能有效改善ASD患者ERP表现。
孤独谱系障碍;重复经颅磁刺激;事件相关电位
Objective To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on the event-related potential (ERP) in children with ASD. Methods 21 ASD children age (7.91±1.55) years were enrolled. All the participants received rTMS and rehabilitation training. ERP and C-PEP were tested at the base-line and 12 weeks after treatment. Results After rTMS treatment, latencies and amplitudes of P300 and N400 improved significantly (P<0.05), as well as total and sub-scales scores of C-PEP (P<0.05). Alteration of P300 and N400 indices were not correlated with changes of C-PEP total score, verbal cognition score and cognitive performance score (P>0.05). Conclusion rTMS could effectively improve the ERP performance in patients with ASD.
Autism spectrum disorder; repetitive transcranial magnetic stimulation; event-related potential