【摘要】

目的：了解精神分裂症患者药物治疗前后事件相关电位（ERP）的变化。
方法：对64例符合ICD-10诊断标准的精神分裂症患者药物治疗前进行事件相关电位检查，通过药物治疗，症状缓解后再进行一次检查，比较治疗前后ERP变化，并与35名健康对照组比较。
结果：精神分裂症患者失匹配负波（MMN）潜伏期延迟大于健康对照组（t=4.8-4.9，P=0.000），信息综合（N2）潜伏期延长大于健康对照组（t=2.13-3.10，P<0.05），认知形成（P300）潜伏期延长大于健康对照组（t=5.3-8.6，P=0.000）。缓解期p300潜伏期延长小于治疗前（t=4.25-5.15，p=0.000），N2治疗前后差异无统计学意义（t=0.21，1.89，P>0.05）。MMN潜伏期延迟仅额部通路（Fz）治疗后小于治疗前（t=2.10，P<0.05）。精神分裂症缓解期MMN、p300潜伏期延迟仍远大于健康对照组（t在4.8-8.6之间，P=0.000），N2潜伏期延长也大健康对照组（t=2.13，3.10，P<0.05）。缓解期顶部通路N2与p300潜伏期延长呈具有统计学意义正相关（r=0.264-0.366, P<0.05，0.01）。
结论：精神分裂症患者存在失匹配负波潜伏期延迟，信息综合潜伏期延长，认知形成过程潜伏期延长。经部分一线抗精神病药物治疗症状缓解后。认知形成有较明显改善，但与健康人群仍有较大差距。负性情绪、信息综合能力无明显改善。信息综合潜伏期延长程度对疗效具有一定预测效应。

【Abstract】

Aim：To find out the change of Event Related Potential(ERP) of patient with schizophrenia before treatment and after treatment remission.
Methods：64 patient were diagnosis schizophrenia by ICD-10 diagnostic criteria，they to do test of ERP before drug treatment，and by drug treatment to remission again to test of ERP，compare the change of ERP before and after treatment，and compare the ERP between patient and 35 people healthy control group.
Results: latent period delay of Mismatch negative wave (MMN) was greater in patient with schizophrenia than in healthy control group（t between 4.8-4.9，P=0.000），and the information synthesis (N2) latent period delay was greater than in healthy control group（t between 2.13-3.10，P<0.05），and the cognitive formation(P300) latent period delay was greater than in healthy control group（t between 5.3-8.6，P=0.000）, latent period delay of P300 was lesser of schizophrenia in remission stage than in before treatment（t between 4.25-5.15，p=0.000），difference not significance of N2 in before treatment than in after treatment（t=0.21，1.89，P>0.05），the latent period delay of MMN only in the forehead passage was lesser in after treatment than in before treatment（t=2.10，P<0.05），latent period delay of MMN、p300 were significantly greater in schizophrenia at remission stage than in healthy control group（t between 4.8-8.6，P=0.000），latent period delay of N2 was greater in schizophrenia than in healthy control group（t=2.13，3.10，P<0.05）, the have significance positive correlation of top path latent period delay between N2 and P300 at remission stage（r between 0.264-0.366, P<0.05，0.01）.
Conclusion  : the patient with schizophrenia are being mismatch negative wave latent period delay, and latent period of information synthesis to prolong, and latent period of cognitive formation process to prolong, by part a gleam of antipsychotic drugs treatment to remission, have significance improvement cognitive formation process, but still existence biggish distance than with healthy people, no significant improvement of negative emotion and information synthesis ability, information synthesis latent period delay degree a certain extent are can forecast to the curative effect.。