【摘要】

摘要 目的 探讨阿立哌唑联合多奈哌齐对精神分裂症患者认知功能、糖脂代谢和血清炎症因子的影响。
方法 按照入院顺序抽签后随机将120例精神分裂症患者分为观察组和对照组，观察组患者给予阿立哌唑联合多奈哌齐治疗，对照组患者给予阿立哌唑联合多奈哌齐模拟片治疗，比较两组治疗效果。
结果 观察组患者总有效率显著高于对照组，差异有统计学意义(P＜0.05)；观察组患者治疗后PANSS评分显著低于对照组，GPT、TMT-A、DST、VFT水平显著高于对照组，差异有统计学意义(P＜0.05)；观察组患者治疗后FBG、2hPBG、TG、TC水平均显著低于对照组，差异有统计学意义(P＜0.05)；观察组患者治疗后血清TNF-α、IL-6、IL-10水平均显著低于对照组，差异有统计学意义(P＜0.05)；两组患者不良反应发生率对比，差异无统计学意义(P＞0.05)。
结论 阿立哌唑联合多奈哌齐对精神分裂症疗效显著，可有效改善患者临床症状、认知功能和炎症因子水平，对糖脂代谢影响小，可作为优选治疗方案。

【Abstract】

Abstract Objective To explore the influence of cognitive function, glucolipid metabolism and inflammatory factor for the patients with schizophrenia by aripiprazole with donepezil.
Methods 120 cases of patients with schizophrenia were randomly divided into observation group(60 cases) and control group(60 cases). The observation group were treated by aripiprazole with donepezil. The control group were treated by aripiprazole with simulation donepezil. The clinical effect were observed.
Results The rate of total effect for the observation group were higher than the control group(P＜0.05); The score for the observation group posttreatment were lower than the control group(P＜0.05); The levels of GPT, TMT-A, DST and VFT for the observation group posttreatment were higher than the control group(P＜0.05); The levels of FBG, 2hPBG, TG and TC for the observation group posttreatment were lower than the control group(P＜0.05); The levels of TNF-α, IL-6 and IL-10 for the observation group posttreatment were lower than the control group(P＜0.05); There was no significant difference on the rate of untoward effect for the two groups(P＞0.05).
Conclusion   It has prominent effect for the patients with schizophrenia by aripiprazole with donepezil. It can improve the clinical symptoms, cognitive function and inflammatory factor. It has small influence for glucolipid metabolism. It can be used as the optimizing treatment.