本刊首页 > 期刊目次 > 氟西汀对高血压伴焦虑抑郁患者血压、情绪状态及不良反应的影响

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氟西汀对高血压伴焦虑抑郁患者血压、情绪状态及不良反应的影响

  • 尹祖斌,李进,段海水,唐世友

* 通信作者: 唐世友, 单位:重庆三峡中心医院平湖分院

摘要

摘要
目的 探讨氟西汀不同用药剂量对高血压伴焦虑抑郁患者血压、情绪状态及不良反应的影响。

方法 按照入院顺序抽签后随机将150例高血压伴焦虑抑郁患者分为A组、B组和C组各50例,三组患者入院后即接受常规降压治疗和盐酸氟西汀胶囊治疗,A组治疗周期为8周,B组治疗周期为12周,C组治疗周期为16周,比较三组治疗效果和安全性。

结果 B、C两组患者治疗后SBP和DBP水平均显著低于A组,差异有统计学意义(P<0.05);B、C两组患者治疗后SAS和SDS水平均显著低于A组,差异有统计学意义(P<0.05);B、C两组患者治疗后血浆NE水平显著低于A组,血浆5-HT水平显著高于A组,差异有统计学意义(P<0.05);C组患者治疗后血浆NE水平显著低于B组,血浆5-HT水平显著高于B组,差异有统计学意义(P<0.05);A、B两组患者治疗期间不良反应发生率均显著低于C组,差异有统计学意义(P<0.05)。

结论 氟西汀能够有效改善高血压伴焦虑抑郁患者的血压、心理状态和血浆NE、5-HT水平,选择12周为治疗周期效果确切,安全性更佳。

关键词:关键词 高血压;焦虑抑郁;氟西汀;治疗周期

ABSTRACT

Abstract
Objective To explore the applicative effect of blood pressure, emotional state and untoward effect in the hypertension associated with anxiety and depression patients by different treatment cycle fluoxetine.

Methods 150 cases of hypertension associated with anxiety and depression patients were randomly divided into A group(50 cases), B group(50 cases) and C group(50 cases). The three groups were treated by conventional treatment + fluoxetine after admission. The treatment cycles for three groups respectively were 8, 12, 16 weeks. The applicative effects and safety were observed.

Results The level of SBP and DBP after treatment for B and C group were lower than A group(P<0.05); The level of SAS and SDS after treatment for B and C group were lower than A group(P<0.05); The level of NE after treatment for B and C group were lower than A group(P<0.05); The level of 5-HT after treatment for B and C group were higher than A group(P<0.05); The level of NE after treatment for C group was lower than B group(P<0.05); The level of 5-HT after treatment for C group was higher than B group(P<0.05); The rate of untoward effect for A and B group were lower than C group(P<0.05).

Conclusion   It can improve the blood pressure, emotional state and levels of NE, 5-HT for the hypertension associated with anxiety and depression patients by fluoxetine. The 12 weeks treatment cycle’s applicative effect is exactly and safety.

Key words: Keywords Hypertension associated; Anxiety and depression; Fluoxetine; Treatment cycle

引用本文 / How to Cite This Article

尹祖斌,李进,段海水,唐世友.氟西汀对高血压伴焦虑抑郁患者血压、情绪状态及不良反应的影响[J]. 国际精神病学杂志, , (): -

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