【摘要】目的 探讨氯沙坦与坎地沙坦酯治疗原发性高血压伴高尿酸血症的临床疗效及内皮祖细胞的修复作用。方法 将2015年1月至2016年5月间我院收治的100例原发性高血压伴高尿酸血症患者随机分为观察组及对照组；观察组患者口服50 mg/d氯沙坦钾片，对照组患者口服4 mg/d坎地沙坦酯；检测患者血压、临床疗效，评估外周血中内皮祖细胞及颈动脉损伤面积，并分析内皮祖细胞及颈动脉损伤面积相关性。结果 观察组临床疗效有效率明显高于对照组，且差异存统计学意义（P<0.05）；两组患者治疗后其收缩压及舒张压均得以显著降低（P<0.05）；治疗后两组患者内皮祖细胞数均显著升高（P<0.05），颈动脉损伤面积显著降低（P<0.05），在治疗后，观察组患者内皮祖细胞数显著高于对照组（P<0.05），且颈动脉损伤面积显著低于对照组（P<0.05）；患者内皮祖细胞及颈动脉损伤面积存显著负相关关系性，相关系数r=-0.298（P<0.05）。结论 采用氯沙坦与坎地沙坦酯对原发性高血压伴高尿酸血症进行治疗均具有较高的临床疗效，并可有限改善患者内皮祖细胞的修复作用，但氯沙坦的临床疗效及内皮祖细胞的修复作用均高于坎地沙坦酯。
[Abstracts]Purposes To investigate the repair effect of losartan and candesartan in treatment of primary hypertension with hyperuricemia and curative effect of endothelial progenitor cells. Methods 100 cases from January 2015 to May 2016 in our hospital from primary hypertension with hyperuricemia were randomly divided into observation group and control group; the observation group were treated by 50 mg/d Losartan Potassium Tablets, the control group were treated with 4 mg/d candesartan cilexetil; detection of blood pressure, clinical efficacy, evaluation of peripheral blood endothelial progenitor cells and carotid artery the damage area, and analyze the area of endothelial progenitor cells and the correlation of carotid artery. Results The clinical curative effect of observation group was significantly higher than the control group, and the difference is statistical significance (P<0.05); two groups of patients after treatment, the systolic blood pressure and diastolic blood pressure were significantly decreased (P<0.05); the two groups after treatment were significantly increased the number of endothelial progenitor cells (P<0.05), the area of carotid artery injury was significantly reduced (P<0.05) after treatment, patients in the observation group, the number of endothelial progenitor cell was significantly higher than the control group (P<0.05), and carotid artery lesion area was significantly lower than the control group (P<0.05); endothelial progenitor cells of patients with carotid artery injury and storage area was negatively correlated, the correlation coefficient r=-0.298 (P<0.05). Conclusion s Use of losartan and candesartan cilexetil on clinical curative effect of primary hypertension with hyperuricemia treatment were high, and can improve the repair effect of limited endothelial progenitor cells, but the repair effect of losartan and curative effect of endothelial progenitor cells were higher than that of candesartan cilexetil.
Key words: Stan; candesartan; hypertension with hyperuricemia; endothelial progenitor cells; repair
引用本文 / How to Cite This Article
洪雁.氯沙坦与坎地沙坦酯对原发性高血压伴高尿酸血症患者的临床疗效及内皮祖细胞的修复作用[J]. 国际精神病学杂志, 2017, 34(11): 1621-1623