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多奈哌齐对老年痴呆者学习记忆功能及事件相关电位的影响

  • 徐世超,刘文滔,饶冬萍,王春江

* 通信作者: 徐世超, 单位:广州医科大学附属脑科医院

摘要

【摘要】
目的 观察多奈哌齐对老年痴呆患者学习记忆功能及事件相关电位的影响。

方法 选取88例老年痴呆患者,按随机数表法分为观察组与对照组,各44例。观察组应用多奈哌齐治疗,对照组应用奥拉西坦。比较两组治疗前后的简易精神状态量表(MMSE)评分、Barthel指数(BI)、事件相关电位及不良反应总发生率。

结果 观察组治疗后的定向力、记忆力、计算能力、回忆能力及学习能力评分与BI指数均高于本组治疗前及对照组(P<0.05)。观察组治疗后Fz区、C3区、C4区的潜伏期均低于本组治疗前及对照组(P<0.05);观察组治疗后Pz、C3区、C4区的波幅均高于本组治疗前及对照组(P<0.05)。两组不良反应总发生率分别13.64%、11.36%,差异P>0.05。

结论 多奈哌齐治疗老年痴呆患者可有效提高患者学习记忆功能与日常生活能力,且Fz、C3、C4区潜伏期缩短与Pz、C3、C4区波幅升高更明显,更利于促进患者认知功能的改善。

关键词:【关键词】老年痴呆;多奈哌齐;学习记忆;事件相关电位

ABSTRACT

【Abstract】
Objective To observe the effect of donepezil on learning and memory function and event- related potential in senile dementia.

Methods 88 patients with senile dementia were selected and divided into observation group and control group according to the random number table, 44 cases in each group. The observation group was treated with donepezil and the control group was treated with Oaxitan.The simple mental state scale(MMSE) score, Barthel index (BI), event-related potential before and after treatment and the total incidence of adverse reactions were compared between two groups.

Results The scores of orientation, memory, computing ability, memory ability and learning ability score and BI index were significantly higher in the observation group than those before treatment and the control group(P<0.05).The latency of Fz, C3 and C4 area in the observation group were lower than those before treatment and in the control group (P<0.05).The amplitude of Pz, C3 and C4 area in the observation group were higher than those before treatment and in the control group (P<0.05). The total incidence of adverse reactions were 13.64% and 11.36% in two groups, the difference was P>0.05.

Conclusion   Donapine treatment of senile dementia patients can effectively improve the learning and memory function and daily living ability, and Fz , C3 , C4 area latency shortened and Pz, C3, C4 area amplitude is more obvious, more conducive to promote cognitive function improve.

Key words: 【Keywords】Senile dementia; Donepezil; Learning and memory; Event-related potentials

引用本文 / How to Cite This Article

徐世超,刘文滔,饶冬萍,王春江.多奈哌齐对老年痴呆者学习记忆功能及事件相关电位的影响[J]. 国际精神病学杂志, 2018, 45(4): 682-685

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