本刊首页 > 期刊目次 > 神经节苷脂治疗早产儿脑室周围白质软化的疗效分析

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神经节苷脂治疗早产儿脑室周围白质软化的疗效分析

  • 张丽

* 通信作者: 张丽, 单位:陕西省渭南市妇幼保健院新生儿科

摘要


目的:分析神经节苷脂( GM-1 )治疗早产儿脑室周围白质软化(PVL)的疗效。

方法:回顾性分析2013年7月~2016年7月50例PVL早产儿的临床资料,对照组23例接受常规治疗及康复训练,以及加用脑活素治疗,研究组27例在对照组治疗基础上给予GM-1治疗。比较两组治疗前后血浆诱导型一氧化氮合酶(iNOS)、白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)浓度,临床疗效及18个月时的智力量表(MDI) 和运动量表( PDI)。

结果:治疗后研究组血浆iNOS、IL-1β、TNF-α浓度明显低于对照组(P<0.05)。研究组有效率明显高于对照组(P<0.05)。研究组PDI 、MDI 评分明显高于对照组(P<0.05),MDI <70分、PDI <70分的比例明显低于对照组(P<0.05)。

结论:GM-1治疗PVL早产儿有一定疗效,其中的机制可能与抑制炎症细胞因子释放,降低iNOS活性,减少NO 参与的神经毒性损伤有关。

关键词:神经节苷脂;早产儿;脑室周围白质软化;诱导型一氧化氮合酶

ABSTRACT


Objective:To analysis the effect of Ganglioside (GM-1) treatment of premature infants with periventricular leukomalacia (PVL) .

Methods: The clinical data of 50 cases of preterm infants with PVL from July 2013 to July 2016 were retrospectively analyzed. 23 patients in the control group received routine treatment and rehabilitation training, and the patients were treated with cerebrolysin. In the study group, 27 cases were treated on the control group Given GM-1 treatment. (I-NOS), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), clinical efficacy and 18-month intelligence scale (P <0.05) MDI) and exercise scale (PDI).

Results:After treatment, the plasma levels of iNOS, IL-1, and TNF- αof the study group were significantly lower than those of the control group (P < 0.05).The effective rate of the study group was significantly higher than that of the control group (P < 0.05).The scores of PDI and MDI of the study group were significantly higher than those of the control group (P < 0.05),and the proportion of MDI<70 and PDI<70 were lower than those of the control group (P < 0.05).

Conclusion  s:GM-1 treatment of premature infants with PVL has a certain effect,and the mechanism may be related to inhibiting the release of inflammatory cytokines, reducing iNOS activity and reducing the neurotoxicity of NO.

Key words: Ganglioside;preterm infants;perivetricular leukomalacia; inducible nitric oxide synthase

引用本文 / How to Cite This Article

张丽.神经节苷脂治疗早产儿脑室周围白质软化的疗效分析[J]. 国际精神病学杂志, 2017, 34(10): 1453-1455

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