本刊首页 > 期刊目次 > 石杉碱甲片在老年痴呆症辅佐治疗中的应用效果及对SAS评分以及SDS评分的影响

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石杉碱甲片在老年痴呆症辅佐治疗中的应用效果及对SAS评分以及SDS评分的影响

  • 张寰, 苏国阳,梁倩,贺鹏,余卫中

* 通信作者: 张寰, 单位:湖北省武汉市第六医院

摘要

【摘要】
目的:探讨石杉碱甲片在老年痴呆症辅佐治疗中的应用效果及对SAS评分以及SDS评分的影响。

方法:对我院神经内科收治的68例老年痴呆症患者进行分组研究,随机分为对照组34例,给予多奈哌齐片治疗,联合组34例,采用多奈哌齐片联合石杉碱甲片治疗,对比两组的应用效果及对SAS评分以及SDS评分的影响。

结果:经过3个月的治疗,联合组总有效率82.35%(28/34)明显高于对照组(67.35%(23/34))(P<0.05);两组治疗前ADL评分与MMSE评分对比无显著差异(P>0.05),治疗3个月后,联合组ADL评分与MMSE评分要显著高于对照组(P<0.05);两组治疗前SAS评分与SDS评分对比无显著差异(P>0.05),治疗3个月后联合组SAS评分与SDS评分要显著低于对照组P<0.05)。

结论:多奈哌齐片是治疗老年痴呆症的常用药物,再加以石杉碱甲片辅佐治疗,其临床疗效更佳,可有效改善患者老年痴呆症状,并缓解老年痴呆症患者的焦虑、抑郁情绪,具有推广应用价值。

关键词:【关键词】石杉碱甲片;老年痴呆症;SAS评分;SDS评分

ABSTRACT

【Abstract】
Objective: To investigate the effect of Huperzine A tablet on adjuvant therapy of Alzheimer's disease and its effect on SAS score and SDS score.

Methods: Sixty-eight patients with Alzheimer's disease were randomly divided into control group (n = 34) and treated with donepezil tablets. The patients were treated with donepezil and Huperzine A tablet. The effect of the group and the effect on the SAS score and the SDS score.

Results: After 3 months of treatment, the total effective rate was 82.35% (28/34) in the combined group was significantly higher than that in the control group (67.35% (23/34)) (P <0.05). The ADL score and MMSE score (P> 0.05). After 3 months of treatment, the scores of ADL and MMSE were significantly higher in the combined group than in the control group (P <0.05). There was no significant difference between the two groups before treatment (P <0.05) > 0.05). After 3 months of treatment, SAS score and SDS score were significantly lower in the combined group than in the control group (P <0.05).

Conclusion  : Donepezil tablets are commonly used drugs for the treatment of Alzheimer's disease, and then combined with Huperzine A tablet, the clinical effect is better, can effectively improve the symptoms of Alzheimer's disease, and alleviate the anxiety and depression of Alzheimer's patients, Promote the application value.

Key words: 【Key words】 Huperzine A tablets; Alzheimer's disease; SAS score; SDS score

引用本文 / How to Cite This Article

张寰, 苏国阳,梁倩,贺鹏,余卫中.石杉碱甲片在老年痴呆症辅佐治疗中的应用效果及对SAS评分以及SDS评分的影响[J]. 国际精神病学杂志, 2017, 44(5): 857-860

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