【摘要】

摘要：目的：探讨综合康复训练联合盐酸多奈哌齐对阿尔茨海默型痴呆(AD)患者康复效果及事件相关电位的影响。
方法：选择2015年1月-2016年12月收治的AD患者112例为研究对象，采用随机数字表法分为观察组和对照组各56例，对照组给予盐酸多奈哌齐治疗，观察组联合综合康复训练，随访3个月，比较两组认知功能、生活质量、事件相关电位。
结果：观察组蒙特利尔认知评估量表（MoCA）评分明显高于对照组，身体健康、精力状况、记忆评分明显高于对照组（P<0.05, P<0.01）；内源性电位N2、P3潜伏期明显短于对照组，P3波幅明显高于对照组（P<0.05, P<0.01）。
结论：综合康复训练联合盐酸多奈哌齐有助于改善阿尔茨海默型痴呆患者认知功能，提高生活质量，可能与调节患者事件相关电位有关。

【Abstract】

Abstract: Objective:To investigate the effect of comprehensive rehabilitation training in combination with donepezil on rehabilitation efficacy of patients with Alzheimer type dementia (AD) and event-related potential. Method：A total of 112 cases of patients with Alzheimer’s disease（AD）from January 2015 to December 2016 were selected as the research objects, and divided into observation group and control group according to the random number table method, with 56 cases in each group. The control group was treated with donepezil hydrochloride, and the observation group was combined with rehabilitation training, After 3 months of follow-up visit, the cognitive function, living quality and event-related potential in the two groups were compared.
Results: The score of Montreal cognitive assessment scale (MoCA) in observation group was significantly higher than that in control group, and the scores of fitness, energy and memory were significantly higher than those in control group (P<0.05, P<0.01); the incubation periods of endogenous potentials N2 and P3 were significantly shorter than those in control group, and the amplitude of P3 was significantly higher than that in control group (P<0.05, P<0.01).
Conclusion  : Comprehensive rehabilitation training in combination with donepezil can help to improve the cognitive function and living quality of AD patients, which may be related to the regulation of the event-related potential of the patients.