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抑郁症与长期住院精神分裂症患者事件相关电位P300对照研究

张振清,王文强,吕娜,陈耀毅,张晨昀,吴娓娓

通讯作者: 王文强，

单位：厦门市仙岳医院

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引用本文: 张振清,王文强,吕娜,陈耀毅,张晨昀,吴娓娓.抑郁症与长期住院精神分裂症患者事件相关电位P300对照研究[J]. 国际精神病学杂志, 2018, 45(3): 426-429

【摘要】

【摘要】目的对照抑郁症与长期住院精神分裂症患者之间事件相关电位P300的特点。
方法对69例抑郁症患者（DD组），69例长期住院精神分裂症患者（SD组）以及70例健康对照患者（HC组）进行对照研究，记录中央点（Cz电极）N1、P2、N2、P3成分。
结果三组之间N1、P2、N2、P3的潜伏期，P3波幅的差异有统计学意义（P＜0.01）。SD组N1、P2、N2、P3潜伏期延长较HC组有统计学意义（P＜0.01），P3波幅减低有统计学意义（P＜0.01）； DD组较HC组N2、P3潜伏期延长，P3波幅减低均有统计学意义（P＜0.01）；SD组N1、P2、N2、P3潜伏期延长较DD组有统计学意义（P＜0.01），P3波幅差异无统计学意义（P=0.787）。
结论长期住院精神分裂症认知受损程度较抑郁症明显，P300可以对抑郁症与精神分裂症的鉴别提供参考。

【关键词】

抑郁症精神分裂症事件相关电位

【Abstract】

【Abstract】 Object To compare the characteristics of the event-related potentials P300 between depression patients and long-term hospitalized schizophrenia patients.
Methods 69 depression patients (DD), 69 long-term hospitalized schizophrenia patients(SD) and 70 healthy controls (HC) were recruited and P300 were detected. N1、P2、N2 and P3 components (Cz) were collected.
Results Significant differences of P300 among three groups were found with both latencies (N1, P2, N2, P3) and amplitude (P3)(P＜0.01). Compared with HC group, the SD group showed prolonged latencies (N1、P1、N2、P3) and decreased amplitude (P3) (P＜0.01). Compared with HC group, the DD group showed prolonged latencies (N2、P3) and decreased amplitude (P3) (P＜0.01). Compared with the DD group, the SD group showed prolonged latencies of N1,P1,N2 and P3 (P＜0.01), except amplitude (P3) (P=0.787).
Conclusion The chronic schizophrenia patients still have cognitive impairment and more than depressive patients. P300 may play a role of differentiating schizophrenia from depression.

【Key words】

Depression; Schizophrenia; Event-related potentials P300

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