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度洛西汀联合小剂量奥氮平治疗抑郁症的临床疗效和不良反应观察

  • 苏亚玲,张明华,汪静,刘静,杨继敏

* 通信作者: 苏亚玲, 单位:北京密云区医院

摘要

摘要
目的:探讨度洛西汀联合小剂量奥氮平治疗抑郁症患者的临床疗效,观察其不良反应的发生情况。

方法:随机将89例抑郁症患者分为实验组(度洛西汀与小剂量奥氮平联合用药)及对照组(度洛西汀单药),实验组45例,对照组44例,治疗8周,应用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)对治疗前及治疗后1、2、4、6、8周两组患者抑郁情况进行评分,比较评分差异,同时观察两组患者不良反应的发生,并进行比较。

结果:对照组治疗有效率为77.3%,实验组治疗有效率88.9%,较对照组明显增高(P<0.05)。从治疗的第21周开始,两组HAMA及HAMD评分不断减低,较治疗前显著下降,差异有显著性(P<0.05);两组间比较,实验组HAMA及HAMD治疗后评分下降程度显著高于对照组,差异具有显著性(P<0.05)。治疗期间两组患者均出现了口干、头晕、体重增加、嗜睡等不良反应,但两组相比差异无显著性(P>0.05)。

结论:度洛西汀联合小剂量奥氮平治疗抑郁症较单药治疗效果显著,且安全可靠。

关键词:关键词:抑郁症;度洛西汀;奥氮平;不良反应

ABSTRACT

Abstract:
Objective:To explore the duloxetine combined with low dose of olanzapine in patients with depression, and observe the occurence of adverse drug reaction.

Methods: 89 cases with depression was selected, and was divided into two groups: experimental group(duloxetine and small dose olanzapine, n=45) and control group(only duloxetine n=44), the duration was 8 weeks, The depression were evaluated with Hamilton depression rating scale (HAMD) and Hamilton anxiety scale (HAMA) before and after therapy. Observe the occurence of adverse drug reaction.

Results: The therapeutic efficacy in control group 77.3%,and in experimental group was 88.9%,The therapeutic efficacy in experimental group was significantly higher than that in control group(P<0.05 ); At the end of 1 week after therapy. The score was decreased on HAMD and HAMA after therapy(P<0.05), but was decreased more in experimental group (P<0.05). The adverse reactions were dry mouth, dizziness, weight gain and lethargy in the two groups, and there was no significant difference between the two groups(P>0.05).

Conclusion  : Duloxetine combining with low dose of olanzapine was more effective than single drug on patients with depression.

Key words: Key words: depression; duloxetine; olanzapine; adverse drug reaction.

引用本文 / How to Cite This Article

苏亚玲,张明华,汪静,刘静,杨继敏.度洛西汀联合小剂量奥氮平治疗抑郁症的临床疗效和不良反应观察[J]. 国际精神病学杂志, 2017, 44(5): 800-803

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