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降压疗法联合帕罗西汀、阿普唑仑治疗老年脑卒中合并焦虑抑郁患者的疗效及对患者SDS、HAMD评分的影响

  • 董太新,谭成万,王京力,黄远芳,刘忆

* 通信作者: 王京力, 单位:湖北省恩施市恩施州优抚医院

摘要

【摘要】
目的:探讨降压治疗联合帕罗西汀、阿普唑仑治疗老年脑卒中合并焦虑抑郁患者的疗效及对患者汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分的影响。

方法:选取2015年1月-2016年1月我院就诊的老年脑卒中合并焦虑抑郁患者74例,按数字奇偶法进行1~74编号,奇数进入对照组,共37例,采取常规降压联合阿米替林治疗,偶数进入观察组,共37例,采取降压治疗联合帕罗西汀、阿普唑仑治疗,比较两组血压变化及用药安全性,同时采用汉密尔顿焦虑量表(HAMA)对患者焦虑症状进行评定,采取汉密尔顿抑郁量表(HAMD)对患者抑郁症状进行评定。

结果:观察组治疗后SBP、DBP水平均低于对照组(P<0.05);而观察组治疗后HAMA、HAMD评分均低于对照组(P<0.05);两组无严重不良反应发生。

结论:对老年脑卒中合并焦虑抑郁患者在常规降压治疗基础上联合帕罗西汀、阿普唑仑治疗的效果较好,改善患者焦虑、抑郁症状,且用药安全。

关键词:【关键词】老年人;脑卒中;降压治疗;帕罗西汀;阿普唑仑

ABSTRACT

【Abstract】
Objective: To investigate the effect of antihypertensive therapy combined with paroxetine and alprazolam on elderly patients with stroke and anxiety and depression, and the effect of Hamilton Anxiety Scale (HAMA),depression and self-rating scale (SDS) and Hamilton Depression Scale (HAMD).

Methods: A total of 74 patients with anxiety and depression enrolled in our hospital from January 2015 to January 2016 were selected, and were numbered 1 to 74 according to the number of parity method, odd into the control group, a total of 37 cases, taking conventional antihypertensive combined with amitriptyline treatment; even into the observation group, a total of 37 cases, taking antihypertensive therapy combined with paroxetine, alprazolam treatment. After 8 weeks of treatment, the changes of blood pressure and drug safety of the two groups were compared. The symptoms of anxiety were evaluated by depressive self - rating scale (SDS), and the depressive symptoms were evaluated byHamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD).

Results: The levels of SBP and DBP in the observation group were lower than those in the control group (P <0.05), while the scores of SDS and HAMD in the observation group were lower than those in the control group (P <0.05), and there were not serious adverse reactions occurred in the two groups.

Conclusion  : The combination of paroxetine and alprazolam in the treatment of elderly patients with stroke and depression is better than conventional antihypertensive therapy, and the symptoms of anxiety and depression are improved and the drug is safe.

Key words: 【Key words】 elderly; stroke; antihypertensive therapy; paroxetine; alprazolam

引用本文 / How to Cite This Article

董太新,谭成万,王京力,黄远芳,刘忆.降压疗法联合帕罗西汀、阿普唑仑治疗老年脑卒中合并焦虑抑郁患者的疗效及对患者SDS、HAMD评分的影响[J]. 国际精神病学杂志, , (): -

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