【摘要】

【摘要】目的 探讨草酸艾司西酞普兰治疗卒中后抑郁（PSD）的疗效及其对患者MMSE评分、ADL评分的影响。
方法 将120例PSD患者随机分为对照组（60例）与观察组（60例），对照组在常规治疗基础上加用疏肝解郁胶囊，观察组在常规治疗基础上加用草酸艾司西酞普兰，采用NIHSS、HAMD、MMSE、ADL进行疗效评价。
结果 组内不同时间点之间各量表评分的比较：治疗前、治疗4周后、治疗24周后，观察组及对照组的NIHSS评分、HAMD评分、MMSE评分、ADL评分比较差异均有统计学意义（P＜0.05）。不同时间点组间各量表评分的比较：治疗前，两组患者各量表评分比较差异无统计学意义（P＞0.05）；治疗4周后，观察组HAMD评分显著低于对照组（P＜0.05），两组患者其余量表评分比较差异无统计学意义（P＞0.05）；治疗24周后，观察组NIHSS评分、HAMD评分显著低于对照组，MMSE评分、ADL评分显著高于对照组，差异有统计学意义（P＜0.05）。
结论 草酸艾司西酞普兰治疗PSD的疗效确切，具有促进神经功能恢复、缓解抑郁症状、改善认知功能障碍、提高日常生活能力等优点。

【Abstract】

【Abstract】Objective To investigate the efficacy of escitalopram oxalate in the treatment of post stroke depression(PSD) and its influence on MMSE scores and ADL scores.
Methods 120 case of PSD were divided into an control group(60 cases) and an observation group(60 cases) randomly, and control group was given Shugan Jieyu capsules baesd on conventional therapy, while observation group received escitalopram oxalate based on conventional therapy,and the efficacy was evaluated by NIHSS, HAMD, MMSE and ADL.
Results The comparison of these scale scores among different time points within the groups showed that the NIHSS scores, HAMD scores, MMSE scores and ADL scores within the observation group and control group had obvious differences among before treatment, 4 weeks after treatment and 24 weeks after treatment(P＜0.05) .The comparison of these scale scores between the 2 groups at different time points showed that there were no obvious differences in these scale scores between the 2 groups before treatment (P＞0.05), while the HAMD scores of observation group were obviously lower than those of control group (P＜0.05), and no obvious differences were found in other scale scores between the 2 groups 4 weeks after treatment(P＞0.05), moreover, the NIHSS scores and HAMD scores of observation group were obviously lower than those of control group(P＜0.05), while the MMSE scores and ADL scores of observation group were obviously higher 24 weeks after treatment(P＜0.05).
Conclusion   The escitalopram oxalate in the treatment of PSD shows good efficacy, which has some advantages such as promoting neurological function recovery, relieving depressive symptoms, improving cognitive dysfunction and activities of daily living.