【摘要】

【摘要】目的：探讨西酞普兰联合米氮平对重度抑郁症伴睡眠障碍症患者睡眠质量、生活质量及氧化应激水平的影响。
方法：选取2015年1月-2017年1月于本院诊治重度抑郁症伴睡眠障碍症患者60例，根据治疗药物不同分为联合组和单药组，各30例，单药组给予西酞普兰治疗，联合组在此基础上给予米氮平治疗，单药组给予西酞普兰治疗，联合组在此基础上给予米氮平，均连续治疗6周，对比分析两组患者治疗前后睡眠质量、生活质量及氧化应激平变化情况。
结果：治疗前两组患者睡眠中质量、生活质量、氧化应激水平均无明显差异（P>0.05）；治疗后，两组患者PSQI 7个因子（睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物及日间活动）评分及总分较治疗前均降低，联合组患者降低程度高于单药组，总症状评分及日常生活评分均高于单药组，超氧化物歧化酶及一氧化氮水平均高于单药组，丙二醛及血浆内皮素-1低于单药组，差异有统计学意义（P<0.05）。
结论：西酞普兰联合米氮平能有效提高重度抑郁症伴睡眠障碍症患者睡眠质量、生活质量，以及改善了氧化应激水平，值得临床作进一步推广。

【Abstract】

【 Abstract】objective: To discuss the effect of mirtazapine combined with escitalopram oxalate on major depressive disorder with sleep disorder of Sleep quality, quality of life and oxidative stress levels.
Methods: 60 major depressive disorder with sleep disorder were selected from January 2015 to January 2017 in our Hospitals. According to Different medications, all patients were divided into observation group (30 cases)and control group(30 cases), observation group was given mirtazapine combined with escitalopram oxalate to treat, control group was given mirtazapine to treat, all were treated for 6 weeks. The quality of sleep, quality of life and the change of oxidative stress in two groups were compared and analyzed.
Results: There was no significant difference in the quality, quality of life, and oxidative stress levels in the two groups(P>0.05). After treatment, two groups of patients with PSQI seven factors (sleep quality, sleep time, sleep time, sleep efficiency, sleep disturbance, hypnotic drugs and daytime activities) score and total score was reduced, the extent of observation group was higher than the control group, the total symptom score and daily life score of the observation group were higher than the control group, The levels of superoxide dismutase and nitric oxide of the observation group was higher than the control group, the total symptom score and daily life score of the o group were higher than the control group, hyperpropylene dialdehyde and plasma endothelial – 1 of the observation group was lower than the control group, the difference was statistically significant (P< 0.05).
Conclusion  s: mirtazapine combined with escitalopram oxalate can effectively improve the sleep quality, quality of life and improved oxidative stress levels in major depressive disorder with sleep disorder, it’s worth for further clinical promotion.