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强效糖皮质激素局部封闭治疗斑秃的临床疗效

  • 吴丹

* 通信作者: 吴丹, 单位:锦州市中心医院皮肤科 121000

摘要


目的 探讨强效糖皮质激素局部封闭治疗斑秃的临床疗效。

方法 选取2014年1月至2015年12月来我院就诊的68例斑秃患者,其中36例行复方倍他米松注射液局部封闭法(试验组),32例行醋酸曲安奈德注射液局部封闭法(对照组)。比较两组患者的治疗有效率、不良反应率和复发率,并分析影响有效率和复发率的危险因素。

结果 试验组的痊愈率、有效率均高于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应及短期复发率比较,差异无统计学意义(P>0.05)。治疗的总有效率为82.35%,短期复发率为19.12%。治疗有效率与年龄、病程、疾病严重程度、治疗方式有关(P<0.05),而短期复发率也与年龄、病程、疾病严重程度有关(P<0.05)。

结论 复方倍他米松局部封闭治疗斑秃优于曲安奈德,但并未改善复发率。发病年龄较小、病程长及重度斑秃患者治疗效果较差,且易复发

关键词:糖皮质激素;封闭治疗;斑秃;疗效

ABSTRACT


Objective To explore the clinical efficacy of topical potent glucocorticoid with local blockade for the patients with alopecia areata.

Methods The clinical data with 68 patients with alopecia areata from Jau. 2014 to Dec. 2015 were reviewed. They were divided into experimental group (n=36) treated with local betamethasone injection and control group (n=32) treated with local triamcinolone acetonide injection. The effective rate, incidence of adverse reaction and recurrence rate between the two groups were compared and the risk factors were analyzed.

Results The curative rate and effective rate in the experimental group were higher than those in the control group (P<0.05). The differences in the incidence of adverse reaction and recurrence rate between the two groups were not statistical (P>0.05). The overall effective rate was 82.35% and short-term recurrence rate was 19.12%. Univariate analysis revealed that the effective rate was associated with onset age, course of disease and treatment methods, and the short-term recurrence rate was also associated with onset age and course of disease (P<0.05).

Conclusion  s Betamethasone with local blockade for the patients with alopecia areata is superior to triamcinolone acetonide, but it can not reduce the recurrence rate. Patients with young, long course of disease and severe alopecia areata has a poor treatment effect and maybe easy to recur.

Key words: Glucocorticoid; Blockade; Alopecia areata; Efficacy

引用本文 / How to Cite This Article

吴丹.强效糖皮质激素局部封闭治疗斑秃的临床疗效[J]. 国际精神病学杂志, , (): -

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