【摘要】

【摘要】 目的 探讨布地奈德混悬液氧气驱动雾化吸入联合维生素A口服
方法防治早产儿支气管肺发育不良（BPD）的临床研究。
方法 选取我院2014年6月～2017年5月新生儿科收治的胎龄＜34周、出生体重＜1500g、出生6h内发生ARDS的早产儿40例，随机分为观察组和对照组。观察组男11例、女9例，患儿在常规治疗的基础上接受布地奈德混悬液氧驱雾化吸入治疗，治疗2个疗程，每个疗程7天；同时口服维生素A1500IU／次，1次／日，连用1周。比较两组患儿血气分析、体重、BPD的发生率。
结果 两组治疗前血气指标PO2、PCO2及体重无统计学意义（p＜0.05。治疗2周后，两组PCO2有所下降，PO2有所上升，体重也有明显提升，观察组变化幅度更大。两组治疗后血气指标、体重比较有统计学差异（p＜0.05）。观察组总吸氧时间显著缩短，p=0.028，BPD发生率显著下降，p=0.038，未发现治疗可能发生的副作用。
结论 对发生ARDS的早产儿，给予布地奈德混悬液氧驱雾化吸入联合维生素A口服治疗，可显著改善血气指标、提高体重增长速度、缩短吸氧时间、降低BPD的发生率。

【Abstract】

Summary Purpose Objective to investigate the clinical efficacy of Budesonide aerosol inhalation and vitamin A oral solution in the prevention and treatment of bronchopulmonary dysplasia (BPD) in premature infants. Method
Methods our hospital from June 2014 to May 2017 in neonatal department, gestational age of less than 34 weeks, birth weight < 1500g, birth 6h occurred in 40 cases of premature infants ARDS, were randomly divided into observation group and control group.The observation group male 11 cases, female 9 cases, patients who received budesonide in the conventional treatment based on the suspension liquid oxygen nebulizer inhalation therapy, treatment for 2 courses, 7 days in each course; at the same time, oral vitamin A1500IU / time, 1 times per day for 1 weeks. Blood gas analysis were compared between the two groups, the incidence rate of weight BPD.Result The two groups before treatment, blood gas indexes PO2, PCO2 and weight was statistically significant (P < 0.05. after 2 weeks of treatment, two groups of PCO2 decreased, PO2 increased, weight has improved significantly, the changes in the observation group were greater. The index of blood gas and weight after treatment in the two groups were statistically significant difference (P < 0.05). The observation group total oxygen time significantly shortened, p=0.028, the incidence rate of BPD decreased significantly, p=0.038, without the side effects of treatment may occur that.
Conclusion   The incidence of ARDS in preterm infants, given budesonide suspension liquid oxygen nebulizer inhalation combined with vitamin A treatment, can significantly improve the blood gas index, increase the weight growth rate, shorten the time of oxygen inhalation, reduce the incidence of BPD.