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奥氮平联合多奈哌齐治疗方案对伴有精神行为症状的阿尔茨海默病治疗的有效性及安全性Meta分析

刘爽,董碧蓉,苏琳,刘颖

通讯作者: 董碧蓉，

单位：四川大学华西医院 610041

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引用本文: 刘爽,董碧蓉,苏琳,刘颖.奥氮平联合多奈哌齐治疗方案对伴有精神行为症状的阿尔茨海默病治疗的有效性及安全性Meta分析[J]. 国际精神病学杂志, , (): -

【摘要】

摘要：目的系统评价在临床中应用奥氮平联合多奈哌齐治疗阿尔茨海默病的总体疗效和安全性。
方法计算机检索 PubMed、EMbase、The Cochrane Library、CNKI、VIP 和 WanFang Data 数据库，搜集应用奥氮平联合多奈哌齐治疗阿尔茨海默病的相关临床研究文献，检索时限从建库至 2017 年 9 月，由两位评价者独立筛选文献、提取资料并评价纳入研究的偏倚风险后，采用 RevＭan 5.3 软件进行 Meta 分析。
结果筛选出质量评价合格文献共 6 篇。应用奥氮平联合多奈哌齐的治疗方案同单独给予奥氮平相比，能够明显增加阿尔茨海默病患者的治疗总有效率和MMSE评分，且差异具有统计学意义（P < 0.05）。
结论在临床中治疗老年阿尔茨海默病可应用奥氮平联合多奈哌齐治疗方案，提高患者的疗效，具有较高的安全性，值得临床广泛推行。

【关键词】

关键词：安全性；meta分析；奥氮平；阿尔茨海默病；疗效

【Abstract】

Abstract: Objective To systematically evaluate the efficacy and safety of olanzapine combined with donepezil on the treatment of Alzheimer's disease.
Methods We electronically searched databases including The CochraneLibrary, PubMed, EMbase, CNKI, WanFang Data and VIP to collect randomized controlled trials (RCTs) about olanzapine with donepezil treatment for Alzheimer's disease from inception to September 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software .
Results A total of 6 literatures of quality evaluation were selected. Treatment program of olanzapine with donepezil could significantly increase the total efficiency and MMSE score of patients with Alzheimer's disease than that of alone olanzapine treatment, and the difference was statistically significant (P < 0.05).
Conclusion olanzapine and donepezil can be used in the treatment of Alzheimer's disease in elderly patients, so as to improve the curative effect and safety of patients, and it is worthy of extensive implementation in clinic.

【Key words】

Keyword: Security; Meta analysis; Olanzapine; Alzheimer's disease; Efficacy

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