【摘要】

摘要：目的：探讨不同用药治疗在延缓老年痴呆患者病情进展中的应用效果。
方法：选取我院2015年1月至2016年1月期间收治的90例老年痴呆患者作为研究对象，按照随机数字表的
方法分为A组（n=30）、B组（n=30）、C组（n=30），其中A组患者使用阿米三嗪药物进行治疗，B组患者使用盐酸多奈哌齐药物进行治疗，C组则使用阿米三嗪联合盐酸多奈哌齐药物治疗。采用简易智能量表（MMSE）对三组患者的认知功能进行评估，同时对三组患者的生活自理能力（ADL）评分和生活质量（SF-36）进行比较，并比较三组患者的药物安全性。
结果：干预前，三组患者的MMSE评分明显低于干预后6周和12周后，其中以C组患者的MMSE评分最低，差异显著（P<0.05）；三组患者干预前的ADL评分明显高于干预后6周和12周后，且C组更高于其他两组（P<0.05）。同时，C组的患者生活质量评分亦明显优于A组和B组，差异显著（P<0.05）；A、B、C组的药物不良反应发生率分别为 ，三组比较差异无统计学意义（P>0.05）。
结论：阿米三嗪联合盐酸多奈哌齐药物治疗可以有效改善老年痴呆患者的认知功能的生活自理能力，且安全性较高，因而值得推广。

【Abstract】

Abstract: Objective: To investigate the efficacy of different drugs in delaying the progression of Alzheimer's disease.
Methods: 90 cases of senile dementia patients in our hospital from January 2015 to January 2016 were treated as the research object, according to the random number table method divided into A group (n=30), B group (n=30), C group (n=30), the A group of patients using alcoholic in drug treatment, group B patients were treated the use of donepezil hydrochloride drug, C group received Amie hydrochloride combined with donepezil hydrochloride three. The simple Intelligence Scale (MMSE) to assess the cognitive function of three groups of patients at the same time, the three groups of patients with self-care ability and quality of life (ADL) score (SF-36) were compared between the three groups, and the drug safety of patients.
Results: before the intervention, three groups of patients with MMSE were significantly lower after 6 weeks and 12 weeks, the patients in the C group MMSE the lowest score, significant difference (P<0.05); the three groups of patients before intervention ADL score was significantly higher than that of intervention after 6 weeks and 12 weeks, and group C was more higher than that of the other two group (P<0.05). At the same time, the quality of life of patients with scores of C group is significantly better than A group and B group, significant difference (P<0.05); adverse drug reactions of A, B and C group respectively, the difference between the three groups was not statistically significant (P>0.05).
Conclusion  : alcoholic combined with donepezil hydrochloride treatment can effectively improve the cognitive function of senile dementia patients with self-care ability, and the safety is high, so it is worth promoting.