【摘要】

[摘要]目的：探讨艾地苯醌联合石杉碱甲治疗老年血管性痴呆的疗效及对患者神经功能、认知水平的影响。
方法：选取我院2013年3月至2017年3月接诊的120例老年血管性痴呆患者展开研究，按照随机数表法，随机均分为研究组和对照组。对照组在老年血管性痴呆常规治疗的基础上加以艾地苯醌治疗，观察组在对照组的基础上加以石杉碱甲治疗。治疗2月后，对两组患者治疗后的疗效、治疗前后的血液流变学指标、治疗前后的MMSE、ADL和CDR评分以及治疗后的不良反应进行比分析。
结果：治疗后，观察组的总有效率明显高于对照组，两组比较差异有统计学意义（P<0.05）。两组患者的血液流变学指标均有所改善，但观察组改善情况大于对照组，两组比较差异有统计学意义（P<0.05）。两组患者的MMSE、ADL评分均有所提高，但观察组明显高于对照组；两组患者的CDR评分均有所下降，但观察组明显低于对照组，两组比较差异有统计学意义（P<0.05）。治疗过程中，两组患者均未出现不良反应而停止用药。
结论：艾地苯醌联合石杉碱甲治疗老年血管性痴呆，疗效显著，能够有效的改善患者的痴呆程度和认知功能，提高其日常生活能力，值得临床上推广及应用。

【Abstract】

[Abstract] Objective To investigate the efficacy of aban combined with huperzine A in elderly patients with vascular dementia and its influence on neurological function and cognitive level.
Methods A total of 120 cases of elderly patients with vascular dementia in our hospital from March 2013 to March 2017 were studied, according to the random number table method, were randomly divided into study group and control group.The control group on the basis of senile vascular dementia to the conventional treatment of idebenone treatment,and to observe the group based on the treatment of huperzine a.After 2 months,the curative effect, blood rheology indexes before and after treatment, MMSE, ADL and CDR scores before and after treatment and adverse reactions after treatment in two groups were compared.
Results After treatment, the total effective rate of the observation group was significantly higher than that of the control group, and the difference between the two groups were statistically significant (P<0.05).The hemorheological indexes of the two groups were improved, but the improvement of the observation group was greater than that of the control group, and the difference between the two groups were statistically significant (P<0.05).The MMSE and ADL score of the two groups were improved, but the observation group was significantly higher than the control group; the CDR score of two groups were decreased, but the observation group was significantly lower than the control group, there was significant difference between two groups (P<0.05).In the course of treatment, two groups of patients showed no adverse reaction and discontinued.
Conclusion  s The efficacy of aban combined with huperzine A is effective in the treatment of senile vascular dementia,and it can effectively improve the degree of dementia and cognitive function of patients, improve their daily living ability, and is worthy of clinical promotion and application.