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沙利度胺联合糖皮质激素治疗10例白塞氏病的疗效分析

  • 仇美琴

* 通信作者: 仇美琴, 单位:南通大学附属东台医院

摘要


目的:观察沙利度胺联合糖皮质激素治疗白塞氏病的临床疗效。

方法:将10例白塞氏综合征患者随机分为治疗组和对照组,每组各5例。对照组给予口服沙利度胺片治疗,观察组在对照组基础上给予泼尼松20mg~30mg/d口服治疗。两组均以一个月为一疗程,共治疗6个疗程。观察两组患者治疗前后临床症状、实验室检查指标红细胞沉降率(ESR)和C反应蛋白(CRP)、血清炎症因子(TNF-α、IL-2和IL-1β)以及免疫球蛋白(IgG、IgA和IgM)水平的变化。

结果:对照组治疗总有效率为40%,观察组治疗总有效率则为60%,差异有统计学意义(P<0.05)。治疗前两组患者炎症因子(TNF-α、IL-2和IL-1β)水平均较高,经治疗后明显降低(P<0.05),实验室检查和免疫学检查

结果表明治疗后ESR、CRP、IgG、IgA和IgM水平亦得到明显改善,且观察组疗效优于对照组(P<0.05)。

结论:沙利度胺联合糖皮质激素治疗白塞氏病疗效较好,可作为临床治疗白塞氏综合征的有效治疗措施之一,具有潜在临床推广价值和应用前景。

关键词:白塞氏病; 沙利度胺; 泼尼松; 临床疗效

ABSTRACT


Objective: To observe the clinical effect of thalidomide combined with glucocorticoids in the treatment of Behcet's disease.

Methods: 10 cases of Behcet's syndrome patients were randomly divided into treatment group and control group (5 cases for each). The control group was treated with thalidomide tablets, and the observation group was given oral administration of prednisone (20 mg~30 mg/d) on the basis of control group. The two groups were treated with one month for one course, and there were 6 courses during the treatment. Clinical symptoms, laboratory indexes of erythrocyte sedimentation rate (ESR) and C reactive protein (CRP), serum inflammatory factor (TNF-α, IL-2 and IL-1β) and immunoglobulin (IgG, IgA and IgM) levels of the patients in the two groups were observed before and after treatment.

Results: Total effective rate of the control group was 40%, and of the observation group was 60%, difference between them was statistically significant (P<0.05). Levels of inflammatory factors (TNF-α, IL-2 and IL-1β) in the two groups before treatment were high, and decreased significantly after treatment (P<0.05). Laboratory and immunological examination showed that after treatment, the levels of ESR, CRP, IgG, IgA and IgM were significantly improved, and the curative effect of the observation group was better than that of the control group (P<0.05).

Conclusion  : Thalidomide combined with glucocorticoids in the treatment of Behcet's disease possess good curative effect, it can be used as one of the effective treatment of Behcet's syndrome, which are provided with important clinical value and wide application prospect.

Key words: Behcet’s disease; thalidomide; prednisone; clinical efficacy

引用本文 / How to Cite This Article

仇美琴.沙利度胺联合糖皮质激素治疗10例白塞氏病的疗效分析[J]. 国际精神病学杂志, , (): -

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