关键词：白塞氏病; 沙利度胺; 泼尼松; 临床疗效
Objective: To observe the clinical effect of thalidomide combined with glucocorticoids in the treatment of Behcet's disease. Methods: 10 cases of Behcet's syndrome patients were randomly divided into treatment group and control group (5 cases for each). The control group was treated with thalidomide tablets, and the observation group was given oral administration of prednisone (20 mg~30 mg/d) on the basis of control group. The two groups were treated with one month for one course, and there were 6 courses during the treatment. Clinical symptoms, laboratory indexes of erythrocyte sedimentation rate (ESR) and C reactive protein (CRP), serum inflammatory factor (TNF-α, IL-2 and IL-1β) and immunoglobulin (IgG, IgA and IgM) levels of the patients in the two groups were observed before and after treatment. Results: Total effective rate of the control group was 40%, and of the observation group was 60%, difference between them was statistically significant (P<0.05). Levels of inflammatory factors (TNF-α, IL-2 and IL-1β) in the two groups before treatment were high, and decreased significantly after treatment (P<0.05). Laboratory and immunological examination showed that after treatment, the levels of ESR, CRP, IgG, IgA and IgM were significantly improved, and the curative effect of the observation group was better than that of the control group (P<0.05). Conclusion : Thalidomide combined with glucocorticoids in the treatment of Behcet's disease possess good curative effect, it can be used as one of the effective treatment of Behcet's syndrome, which are provided with important clinical value and wide application prospect.
Key words: Behcet’s disease; thalidomide; prednisone; clinical efficacy
引用本文 / How to Cite This Article
仇美琴.沙利度胺联合糖皮质激素治疗10例白塞氏病的疗效分析[J]. 国际精神病学杂志, , (): -