【摘要】

【摘要】目的 探讨小剂量左乙拉西坦添加疗法联合丙戊酸钠对成人初治局灶性癫痫近期疗效及对社会功能的影响。
方法 将104例初治局灶性癫痫成人患者随机两组：对照组（n=52）予以丙戊酸钠单药治疗，观察组（n=52）在对照组基础上予以小剂量左乙拉西坦添加治疗，疗程6个月。比较两组临床疗效及不良反应，治疗前后采用社会功能缺陷筛选量表（SDSS）评价社会功能，采用癫痫患者生活质量评定量表（QOLIE-31）评价生活质量。
结果 治疗3、6个月末，观察组总有效率（71.15%、80.77%）明显高于对照组（53.85%、65.38%），且观察组SDSS各维度评分显著低于对照组，而QOLIE-31量表各维度评分均明显高于对照组，比较差异均有统计学意义（均P<0.05）；观察组不良反应率（7.69%）与对照组（5.77%）比较差异无统计学意义（P>0.05）。
结论 小剂量左乙拉西坦添加疗法联合丙戊酸钠治疗成人初治局灶性癫痫安全有效，能够改善患者的社会功能及生活质量。

【Abstract】

【Abstract】 Objective To investigate the short-term prognosis of low dose of levetiracetam additive treatment combined with sodium valproate for adult patients with newly diagnosed partial epilepsy and its influence on social function.
Methods 104 cases of adult patients with partial epilepsy were randomly divided into two groups:the control group (n = 52) was treated with sodium valproate,the observation group (n=52) was given a low dose of levetiracetam additive treatment on the basis of the control group for 6 months. The clinical efficacy and adverse reactions between the two groups were compared,the social function was evaluated by Social Function Defect Screening Scale (SDSS) and quality of life was evaluated by Quality of Life in Epilepsy-31 Scale (QOLIE-31) before and after treatment.
Results At the end of 3 and 6 months of treatment, the total effective ratein the observation group (71.15%, 80.77%) were significantly higher than that in the control group (53.85%, 65.38%), the scores of each dimension of SDSS in observation group were significantly lower than the control group,while the scores of QOLIE-31 were significantly higher than those in the control group (P<0.05). There adverse reaction rate between the observation group (7.69%) and the control group (5.77%) was no significant difference (P>0.05).
Conclusion   Low-dose levetiracetam additive treatment combined with sodium valproate is safe and effective for adult patients with newly diagnosed partial epilepsy,which can improve the social function and quality of life of patients.