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肺癌合并肺栓塞患者的临床相关因素分析

  • 朱璐,覃寿明,巫艳彬

* 通信作者: 覃寿明, 单位:广西医科大学第一附属医院 530021

摘要

【摘要】
目的:探讨肺癌患者临床因素与肺栓塞发生的相关性,提高临床医师对肺癌患者并发肺栓塞的警惕性,及时发现肺栓塞,尽早治疗肺栓塞及调整肺癌治疗方案。

方法:采用1:3配比设计的病例对照研究

方法,收集广西医科大学第一附属医院2014年01月至2017年06月收入院的肺癌并发肺栓塞的51例患者为病例组(A组),以及未并发肺栓塞的153例肺癌患者为对照组(B组),分析两组实验室检查、病理类型、TNM分期、肿瘤治疗方式等指标的差异。

结果:两组患者的体重指数、纤维蛋白原测定、血红蛋白升高占比、病理类型、是否吸烟及患高血压病、肺癌治疗方式(是否化疗)构成比差异无统计学意义(P>0.05)。两组患者血小板计数升高者占比、红细胞比容平均值、D-二聚体定量、TNM分期、解剖类型构成比差异有统计学意义(P<0.05)。Logistic多因素回归分析显示,血小板计数升高、D-二聚体定量OR值分别为5.33、26.902,差异具有统计学意义(P<0.05)。

结论:D-二聚体升高是肺癌并发肺栓塞的独立危险因素。晚期、周围型肺癌者更易并发肺栓塞。血小板升高并未增加肺癌患者发生肺栓塞风险。血红蛋白、纤维蛋白原对肺栓塞提示意义不大。体重指数、肿瘤治疗方式(是否化疗)、病理类型、有吸烟史及高血压病史对肺栓塞的发生无明显影响。

关键词:肺癌;肺栓塞;临床分析

ABSTRACT

【Abstract】
Objective: To investigate the correlation between clinical factors and pulmonary embolism in patients with lung cancer and to improve clinicians' vigilance against pulmonary embolism in patients with lung cancer and detect pulmonary embolism in time so as to treat pulmonary embolism and adjust tumor therapies as early as possible.

Methods:A case-control study with a 1: 3 ratio design was conducted by collect 51 cases with lung cancer complicated with pulmonary embolism who Comply with inclusion and exclusion criteria in the First Affiliated Hospital of Guangxi Medical University from January 2014 to June 2017 as case group(group A).and another 153 cases of lung cancer without pulmonary embolism were collected as the control group(group B).To analyze the difference between the two groups laboratory tests, pathological types, TNM Classification, lung cancer therapies and other indicators.

Results:Body mass index, fibrinogen measurement, the proportion of hemoglobin increased, pathological type, whether smoking and hypertension, lung cancer treatment (whether chemotherapy) composition ratio between the two groups has not statistically significant(P>0.05).The two groups of patients with elevated platelet count, hematocrit average, D-dimer, TNM stage, anatomical types constitute a statistically significant difference(P<0.05).Logistic multivariate regression analysis showed that platelet count increased, D-dimer quantitative OR was 5.33,26.902, the difference was statistically significant(P<0.05).

Conclusion  : D-dimer is an independent risk factor for pulmonary embolism in patients with lung cancer, Advanced , peripheral lung cancer are more complicated with pulmonary embolism. Elevated platelets in patients with lung cancer did not increase the risk of pulmonary embolism.hemoglobin, fibrinogen on pulmonary embolism prompted little. Body mass index,Tumor treatment (whether chemotherapy), pathological type, whether smoking and history of hypertension had no significant effect on the occurrence of pulmonary embolism.

Key words: Lung cancer;Pulmonary embolism;Clinical analysis

引用本文 / How to Cite This Article

朱璐,覃寿明,巫艳彬.肺癌合并肺栓塞患者的临床相关因素分析[J]. 国际精神病学杂志, 2018, 35(4): 476-479

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